|Impairment of recovery of muscle function by residual rocuronium after re-transfusion of intraoperative salvaged blood|
|Wang Geng1; Wang Jia1; Zhou Haibin1; Zhao Xia1; Wu Xinmin2|
|关键词||intraoperative blood salvage neuromuscular blocking agents rocuronium recurarization|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||CELL SALVAGE ; NEUROMUSCULAR BLOCKADE ; PULMONARY-FUNCTION ; ANESTHESIA ; WITHDRAWN ; INJECTION ; RELAXANTS ; SURGERY ; RISK|
Background Recurarization has previously been described in the context of acute normovolemic hemodilution. The aim of this study was to investigate the impairment of recovery of neuromuscular function after re-transfusion of intraoperative salvaged blood in patients treated with rocuronium.
Methods We enrolled 50 patients undergoing general anesthesia for lumbar surgery. Intraoperative blood salvage (IBS) was used in 30 patients (group I); the remaining 20 comprised a control group (group C). Anesthesia was induced with fentanyl, midazolam, propofol and rocuronium. Rocuronium was infused to maintain neuromuscular blockade during surgery. Blood was collected from the operative field and re-transfused in the post-anesthesia care unit (PACU). Neuromuscular function was monitored using the train-of-four ratio (TOFr). Once the train-of-four ratio exceeded 90 in the PACU, neuromuscular function was evaluated every 5 minutes for 30 minutes. The TOFr and incremental recovery of TOFr from baseline were recorded. Salvaged blood was re-transfused at the beginning of the evaluation for patients in group I, and afterwards for patients in group C. Blood gas analysis was assessed before anesthesia and in the PACU.
Results Incremental recovery of TOFr from baseline was significantly less in group I than controls at 25 minutes (6.1 +/- 3.2 vs. 9.1 +/- 3.2, respectively; P=0.001) and 30 minutes (7.1 +/- 3.2 vs. 10.0 +/- 2.2, respectively; P=0.001). There were no significant differences in gas exchange between the groups.
Conclusions In patients who had received a rocuronium infusion during anesthesia, re-transfusion of salvaged blood significantly impaired recovery of neuromuscular function recovery in the PACU, but without significant impairment of respiratory function.
|作者单位||1.Beijing Jishuitan Hosp, Dept Anesthesiol, Beijing 100035, Peoples R China|
2.Peking Univ, Hosp 1, Dept Anesthesiol, Beijing 100034, Peoples R China
|Wang Geng,Wang Jia,Zhou Haibin,et al. Impairment of recovery of muscle function by residual rocuronium after re-transfusion of intraoperative salvaged blood[J]. CHINESE MEDICAL JOURNAL,2014,127(5):821-824.|
|APA||Wang Geng,Wang Jia,Zhou Haibin,Zhao Xia,&Wu Xinmin.(2014).Impairment of recovery of muscle function by residual rocuronium after re-transfusion of intraoperative salvaged blood.CHINESE MEDICAL JOURNAL,127(5),821-824.|
|MLA||Wang Geng,et al."Impairment of recovery of muscle function by residual rocuronium after re-transfusion of intraoperative salvaged blood".CHINESE MEDICAL JOURNAL 127.5(2014):821-824.|