北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation
作者: Huang, C; Wang, Y; Chang, JK; Han, JS
关键词: endomorphin ; mu-opioid receptor ; receptor antagonist ; analgesia ; antiserum ; electroacupuncture
刊名: NEUROSCIENCE LETTERS
发表日期: 2000-11-24
卷: 294, 期:3, 页:159-162
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: FREQUENCIES ; RAT
英文摘要:

This work was designed to examine whether brain endomorphins (EM1 and EM2), the endogenous mu -opioid ligands, are involved in electroacupuncture (EA)-induced analgesia in the mice: C57BL/6J mice were given EA for 30 min a nd the effect of EA-induced analgesia was assessed by radiant heat tail flick latency (TFL). Intracerebroventricular (i.c.v.) injection of mu -opioid receptor antagonist D-Phe-Cys-Tyr-D-Tyr-Orn-Thr-Pen-Thr-NH2 (CTOP), or antiserum against EM1 or EM2 was performed to see whether EA analgesia could be blocked. The results showed that: (1) i.c.v. injection of CTOP at 25-100 ng dose-dependently antagonized the analgesia induced by EA of 2 Hz, but not 100 Hz. (2) Intracerebroventricular injection of EM1 antiserum (5 mi, 1:1 or 1:10 dilution) dose-dependently antagonized 2 Hz, but not 100 Hz EA analgesia. (3) EM2 antiserum showed similar effect at 1:1 dilution. The results are interpreted to mean that endogenously released EM1 and EM2 and the cerebral mu -receptors are involved in mediating 2 Hz but not 100 Hz EA analgesia in the mice. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000165397300007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60744
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation.pdf(227KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Phoenix Pharmaceut Inc, California, CA 93505 USA

Recommended Citation:
Huang, C,Wang, Y,Chang, JK,et al. Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation[J]. NEUROSCIENCE LETTERS,2000,294(3):159-162.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, C]'s Articles
[Wang, Y]'s Articles
[Chang, JK]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, C]‘s Articles
[Wang, Y]‘s Articles
[Chang, JK]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace