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学科主题: 基础医学
题名:
Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation
作者: Huang, C; Wang, Y; Chang, JK; Han, JS
关键词: endomorphin ; mu-opioid receptor ; receptor antagonist ; analgesia ; antiserum ; electroacupuncture
刊名: NEUROSCIENCE LETTERS
发表日期: 2000-11-24
卷: 294, 期:3, 页:159-162
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: FREQUENCIES ; RAT
英文摘要:

This work was designed to examine whether brain endomorphins (EM1 and EM2), the endogenous mu -opioid ligands, are involved in electroacupuncture (EA)-induced analgesia in the mice: C57BL/6J mice were given EA for 30 min a nd the effect of EA-induced analgesia was assessed by radiant heat tail flick latency (TFL). Intracerebroventricular (i.c.v.) injection of mu -opioid receptor antagonist D-Phe-Cys-Tyr-D-Tyr-Orn-Thr-Pen-Thr-NH2 (CTOP), or antiserum against EM1 or EM2 was performed to see whether EA analgesia could be blocked. The results showed that: (1) i.c.v. injection of CTOP at 25-100 ng dose-dependently antagonized the analgesia induced by EA of 2 Hz, but not 100 Hz. (2) Intracerebroventricular injection of EM1 antiserum (5 mi, 1:1 or 1:10 dilution) dose-dependently antagonized 2 Hz, but not 100 Hz EA analgesia. (3) EM2 antiserum showed similar effect at 1:1 dilution. The results are interpreted to mean that endogenously released EM1 and EM2 and the cerebral mu -receptors are involved in mediating 2 Hz but not 100 Hz EA analgesia in the mice. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000165397300007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60744
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Phoenix Pharmaceut Inc, California, CA 93505 USA

Recommended Citation:
Huang, C,Wang, Y,Chang, JK,et al. Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation[J]. NEUROSCIENCE LETTERS,2000,294(3):159-162.
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