IR@PKUHSC  > 北京大学第三临床医学院  > 消化科
学科主题临床医学
Atrophy and intestinal metaplasia one year after cure of H-pylori infection: A prospective, randomized study
Sung, JJY; Lin, SR; Ching, JYL; Zhou, LY; To, KF; Wang, RT; Leung, WK; Ng, EKW; Lau, JYW; Lee, YT; Yeung, CK; Chao, W; Chung, SCS
刊名GASTROENTEROLOGY
2000-07-01
119期:1页:7-14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]HELICOBACTER-PYLORI ; GASTRIC-CANCER ; FOLLOW-UP ; ERADICATION ; CAGA ; COUNTRY ; RISK ; AGE
英文摘要

Background & Aims: Helicobacter pylori-infected gastric mucosa evolves through stages of chronic gastritis, intestinal metaplasia (IM), glandular atrophy (GA), and dysplasia before carcinoma develops. We studied if H. pylori eradication would alter the course of premalignant histologic changes in the stomach. Methods: Volunteers from the Yantai County in China underwent upper endoscopy with biopsy specimens obtained from the antrum and corpus. H. pylori-infected subjects were randomized to receive either a 1-week course of omeprazole, amoxicillin, and clarithromycin (OAC) or placebo. At 1 year, endoscopies with biopsies were repeated. Results: A total of 587 H. pylori-infected subjects were randomized to OAC (n = 295) and placebo (n = 292), At 1 year, H, pylori was eradicated in 226 subjects assigned to OAC. In the placebo group, 245 patients remained H. pylori infected. Analysis of paired samples obtained from the same patients showed that acute and chronic gastritis decreased in both the antrum and corpus after H. pylori eradication (P < 0.001) and activity of IM decreased in antrum (P = 0.014). In the H, pylori-infected group, antral biopsy specimens had more pronounced acute gastritis (P = 0.01), whereas corpus specimens showed increased acute and chronic gastritis (P < 0.001) and a marginal increase in GA (P = 0.052). When histologic changes were compared between the 2 groups, decrease in acute and chronic gastritis was more frequent after H. pylori eradication (P < 0.001) but changes in IM were similar. In the H. pylori-infected group, increase in GB was seen in the corpus IP = 0.01). Conclusions: At 1 year, H. pylori eradication is beneficial in preventing progression of pathologic changes of the gastric mucosa.

语种英语
WOS记录号WOS:000088108800005
引用统计
被引频次:239[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60746
专题北京大学第三临床医学院_消化科
作者单位1.Chinese Univ Hong Kong, Endoscopy Ctr, Hong Kong, Hong Kong, Peoples R China
2.Beijing Med Univ, Dept Gastroenterol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Sung, JJY,Lin, SR,Ching, JYL,et al. Atrophy and intestinal metaplasia one year after cure of H-pylori infection: A prospective, randomized study[J]. GASTROENTEROLOGY,2000,119(1):7-14.
APA Sung, JJY.,Lin, SR.,Ching, JYL.,Zhou, LY.,To, KF.,...&Chung, SCS.(2000).Atrophy and intestinal metaplasia one year after cure of H-pylori infection: A prospective, randomized study.GASTROENTEROLOGY,119(1),7-14.
MLA Sung, JJY,et al."Atrophy and intestinal metaplasia one year after cure of H-pylori infection: A prospective, randomized study".GASTROENTEROLOGY 119.1(2000):7-14.
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