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学科主题: 临床医学
题名:
Atrophy and intestinal metaplasia one year after cure of H-pylori infection: A prospective, randomized study
作者: Sung, JJY; Lin, SR; Ching, JYL; Zhou, LY; To, KF; Wang, RT; Leung, WK; Ng, EKW; Lau, JYW; Lee, YT; Yeung, CK; Chao, W; Chung, SCS
刊名: GASTROENTEROLOGY
发表日期: 2000-07-01
卷: 119, 期:1, 页:7-14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HELICOBACTER-PYLORI ; GASTRIC-CANCER ; FOLLOW-UP ; ERADICATION ; CAGA ; COUNTRY ; RISK ; AGE
英文摘要:

Background & Aims: Helicobacter pylori-infected gastric mucosa evolves through stages of chronic gastritis, intestinal metaplasia (IM), glandular atrophy (GA), and dysplasia before carcinoma develops. We studied if H. pylori eradication would alter the course of premalignant histologic changes in the stomach. Methods: Volunteers from the Yantai County in China underwent upper endoscopy with biopsy specimens obtained from the antrum and corpus. H. pylori-infected subjects were randomized to receive either a 1-week course of omeprazole, amoxicillin, and clarithromycin (OAC) or placebo. At 1 year, endoscopies with biopsies were repeated. Results: A total of 587 H. pylori-infected subjects were randomized to OAC (n = 295) and placebo (n = 292), At 1 year, H, pylori was eradicated in 226 subjects assigned to OAC. In the placebo group, 245 patients remained H. pylori infected. Analysis of paired samples obtained from the same patients showed that acute and chronic gastritis decreased in both the antrum and corpus after H. pylori eradication (P < 0.001) and activity of IM decreased in antrum (P = 0.014). In the H, pylori-infected group, antral biopsy specimens had more pronounced acute gastritis (P = 0.01), whereas corpus specimens showed increased acute and chronic gastritis (P < 0.001) and a marginal increase in GA (P = 0.052). When histologic changes were compared between the 2 groups, decrease in acute and chronic gastritis was more frequent after H. pylori eradication (P < 0.001) but changes in IM were similar. In the H. pylori-infected group, increase in GB was seen in the corpus IP = 0.01). Conclusions: At 1 year, H. pylori eradication is beneficial in preventing progression of pathologic changes of the gastric mucosa.

语种: 英语
WOS记录号: WOS:000088108800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60746
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Endoscopy Ctr, Hong Kong, Hong Kong, Peoples R China
2.Beijing Med Univ, Dept Gastroenterol, Beijing, Peoples R China

Recommended Citation:
Sung, JJY,Lin, SR,Ching, JYL,et al. Atrophy and intestinal metaplasia one year after cure of H-pylori infection: A prospective, randomized study[J]. GASTROENTEROLOGY,2000,119(1):7-14.
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