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Stromal-derived factor-1 deficiency in the bone marrow of acute myeloid leukemia
Ge, Jian; Hou, Ruiqin; Liu, Quanhua; Zhu, Rongjia; Liu, Kaiyan
关键词Mesenchymal stem cells Bone marrow Stromal-derived factor-1 Acute myeloid leukemia Migration
刊名INTERNATIONAL JOURNAL OF HEMATOLOGY
2011-06-01
DOI10.1007/s12185-011-0869-9
93期:6页:750-759
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]MESENCHYMAL STEM-CELLS ; CHEMOKINE RECEPTORS ; PROMOTING MIGRATION ; PROGENITOR CELLS ; TRANSPLANTATION ; CXCR4 ; ENGRAFTMENT ; REPOPULATION ; RECOVERY ; EXPRESS
英文摘要

Chemokine stromal-derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to play an important role in the migration and homing of the transplanted hematopoietic stem cells (HSCs). Mesenchymal stem cells (MSCs) express these molecules. This study is to test the hypothesis that acute myeloid leukemia (AML) alters the expression of SDF-1/CXCR4 in human bone marrow MSCs. Expression of both CXCR4 and SDF-1 was found to be increased, but excessively retained, in the MSCs in AML. In contrast, the SDF-1 level in bone marrow plasma and supernatant of cultured MSCs from AML patients were reduced, while the SDF-1 was able to efficiently induce a dose-dependent migration of MSCs in vitro. Our results demonstrate that altered expression and distribution of SDF-1/CXCR4 in MSCs may contribute to SDF-1 deficiency in the plasma of AML patients. The migration of MSCs may be negatively affected by the SDF-1 deficiency.

语种英语
WOS记录号WOS:000291396600011
项目编号2006AA02A109
资助机构Ministry of Science and Technology of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60748
专题北京大学第二临床医学院_血液科
北京大学第二临床医学院_输血科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Ge, Jian,Hou, Ruiqin,Liu, Quanhua,et al. Stromal-derived factor-1 deficiency in the bone marrow of acute myeloid leukemia[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2011,93(6):750-759.
APA Ge, Jian,Hou, Ruiqin,Liu, Quanhua,Zhu, Rongjia,&Liu, Kaiyan.(2011).Stromal-derived factor-1 deficiency in the bone marrow of acute myeloid leukemia.INTERNATIONAL JOURNAL OF HEMATOLOGY,93(6),750-759.
MLA Ge, Jian,et al."Stromal-derived factor-1 deficiency in the bone marrow of acute myeloid leukemia".INTERNATIONAL JOURNAL OF HEMATOLOGY 93.6(2011):750-759.
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