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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Stromal-derived factor-1 deficiency in the bone marrow of acute myeloid leukemia
作者: Ge, Jian; Hou, Ruiqin; Liu, Quanhua; Zhu, Rongjia; Liu, Kaiyan
关键词: Mesenchymal stem cells ; Bone marrow ; Stromal-derived factor-1 ; Acute myeloid leukemia ; Migration
刊名: INTERNATIONAL JOURNAL OF HEMATOLOGY
发表日期: 2011-06-01
DOI: 10.1007/s12185-011-0869-9
卷: 93, 期:6, 页:750-759
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: MESENCHYMAL STEM-CELLS ; CHEMOKINE RECEPTORS ; PROMOTING MIGRATION ; PROGENITOR CELLS ; TRANSPLANTATION ; CXCR4 ; ENGRAFTMENT ; REPOPULATION ; RECOVERY ; EXPRESS
英文摘要:

Chemokine stromal-derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to play an important role in the migration and homing of the transplanted hematopoietic stem cells (HSCs). Mesenchymal stem cells (MSCs) express these molecules. This study is to test the hypothesis that acute myeloid leukemia (AML) alters the expression of SDF-1/CXCR4 in human bone marrow MSCs. Expression of both CXCR4 and SDF-1 was found to be increased, but excessively retained, in the MSCs in AML. In contrast, the SDF-1 level in bone marrow plasma and supernatant of cultured MSCs from AML patients were reduced, while the SDF-1 was able to efficiently induce a dose-dependent migration of MSCs in vitro. Our results demonstrate that altered expression and distribution of SDF-1/CXCR4 in MSCs may contribute to SDF-1 deficiency in the plasma of AML patients. The migration of MSCs may be negatively affected by the SDF-1 deficiency.

语种: 英语
所属项目编号: 2006AA02A109
项目资助者: Ministry of Science and Technology of China
WOS记录号: WOS:000291396600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60748
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Ge, Jian,Hou, Ruiqin,Liu, Quanhua,et al. Stromal-derived factor-1 deficiency in the bone marrow of acute myeloid leukemia[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2011,93(6):750-759.
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