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学科主题: 药学
题名:
Rupestonic acids B-G, NO inhibitory sesquiterpenoids from Artemisia rupestris
作者: Zhang, Chen1; Wang, Shu2; Zeng, Ke-Wu1; Cui, Feng-Xia3; Jin, Hong-Wei1; Guo, Xiao-Yu1; Jiang, Yong1; Tu, Peng-Fei1
关键词: Artemisia rupestris ; Sesquiterpenoids ; Rupestonic acids B-G ; Absolute configurations ; NO inhibition
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2014-09-01
DOI: 10.1016/j.bmcl.2014.07.008
卷: 24, 期:17, 页:4318-4322
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: NITRIC-OXIDE ; IDENTIFICATION ; CHROMATOGRAPHY ; GUAIANOLIDES ; DERIVATIVES ; TERPENOIDS ; ALKALOIDS ; LACTONES ; VESTITA ; L.
英文摘要:

Six new guaiane sesquiterpenoids, rupestonic acids B-G (1-6), have been isolated from the whole plants of Artemisia rupestris together with six known compounds (7-12). The structures of the new isolates (1-6) were elucidated on the basis of extensive 1D and 2D NMR analysis, and the absolute configurations were established by electronic circular dichroism (ECD) in combination with density functional theory calculations. In in vitro bioassays, compounds 2 and 6 exhibited significant inhibitory effects on LPS-stimulated NO production in BV-2 microglial cells with IC50 values of 2.6 and 2.2 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30973629 ; 81373294 ; 81222051 ; 81303253 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
项目资助者: National Natural Science Foundation of China ; National Key Technology R&amp ; D Program &prime ; New Drug Innovation&prime ; of China
WOS记录号: WOS:000341339300049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60755
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Logist Coll Chinese Peoples Armed Police Forces, Dept Med Chem & Pharmaceut Anal, Tianjin 300162, Peoples R China
3.Chengde Med Univ, Key Lab Tradit Chinese Res & Dev Hebei Prov, Chengde 067000, Peoples R China

Recommended Citation:
Zhang, Chen,Wang, Shu,Zeng, Ke-Wu,et al. Rupestonic acids B-G, NO inhibitory sesquiterpenoids from Artemisia rupestris[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(17):4318-4322.
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