IR@PKUHSC  > 北京大学药学院
学科主题药学
Rupestonic acids B-G, NO inhibitory sesquiterpenoids from Artemisia rupestris
Zhang, Chen1; Wang, Shu2; Zeng, Ke-Wu1; Cui, Feng-Xia3; Jin, Hong-Wei1; Guo, Xiao-Yu1; Jiang, Yong1; Tu, Peng-Fei1
关键词Artemisia rupestris Sesquiterpenoids Rupestonic acids B-G Absolute configurations NO inhibition
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2014-09-01
DOI10.1016/j.bmcl.2014.07.008
24期:17页:4318-4322
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]NITRIC-OXIDE ; IDENTIFICATION ; CHROMATOGRAPHY ; GUAIANOLIDES ; DERIVATIVES ; TERPENOIDS ; ALKALOIDS ; LACTONES ; VESTITA ; L.
英文摘要

Six new guaiane sesquiterpenoids, rupestonic acids B-G (1-6), have been isolated from the whole plants of Artemisia rupestris together with six known compounds (7-12). The structures of the new isolates (1-6) were elucidated on the basis of extensive 1D and 2D NMR analysis, and the absolute configurations were established by electronic circular dichroism (ECD) in combination with density functional theory calculations. In in vitro bioassays, compounds 2 and 6 exhibited significant inhibitory effects on LPS-stimulated NO production in BV-2 microglial cells with IC50 values of 2.6 and 2.2 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000341339300049
项目编号30973629 ; 81373294 ; 81222051 ; 81303253 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
资助机构National Natural Science Foundation of China ; National Key Technology R&amp ; D Program &prime ; New Drug Innovation&prime ; of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60755
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_天然药物学系
北京大学临床肿瘤学院_淋巴肿瘤内科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Logist Coll Chinese Peoples Armed Police Forces, Dept Med Chem & Pharmaceut Anal, Tianjin 300162, Peoples R China
3.Chengde Med Univ, Key Lab Tradit Chinese Res & Dev Hebei Prov, Chengde 067000, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chen,Wang, Shu,Zeng, Ke-Wu,et al. Rupestonic acids B-G, NO inhibitory sesquiterpenoids from Artemisia rupestris[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(17):4318-4322.
APA Zhang, Chen.,Wang, Shu.,Zeng, Ke-Wu.,Cui, Feng-Xia.,Jin, Hong-Wei.,...&Tu, Peng-Fei.(2014).Rupestonic acids B-G, NO inhibitory sesquiterpenoids from Artemisia rupestris.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(17),4318-4322.
MLA Zhang, Chen,et al."Rupestonic acids B-G, NO inhibitory sesquiterpenoids from Artemisia rupestris".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.17(2014):4318-4322.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Chen]的文章
[Wang, Shu]的文章
[Zeng, Ke-Wu]的文章
百度学术
百度学术中相似的文章
[Zhang, Chen]的文章
[Wang, Shu]的文章
[Zeng, Ke-Wu]的文章
必应学术
必应学术中相似的文章
[Zhang, Chen]的文章
[Wang, Shu]的文章
[Zeng, Ke-Wu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。