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Effects of neferine on the pharmacokinetics of amiodarone in rats
Wan, Jiadao1; Zhao, Libo2; Xu, Chuan3,4; Zhang, Shaohui5; Zhang, Zhixin1; Zeng, Cheng1; Chang, Mujun1; Xiao, Junhua1; Wang, Jialing1
关键词amiodarone neferine pharmacokinetic interaction RP-HPLC cytochrome P450
刊名BIOMEDICAL CHROMATOGRAPHY
2011-08-01
DOI10.1002/bmc.1535
25期:8页:858-866
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]INDUCED PULMONARY-FIBROSIS ; ATRIAL-FIBRILLATION ; PREVENTION ; THERAPY ; ISOLIENSININE ; PIRFENIDONE ; DRONEDARONE ; WARFARIN ; CELLS
英文摘要

Amiodarone, an iodinated benzofuran derivative with predominantly class III anti-arrhythmic effects, is used to treat supraventricular and ventricular arrhythmias. The purpose of this study was to assess the potential of neferine, an effective anti-pulmonary fibrosis drug isolated from the embryo of Nelumbo nucifera Gaertner′s seeds, to alter the pharmacokinetic profile of amiodarone. Experimental Sprague-Dawley rats were randomly divided into two groups. In groups 1 and 2, amiodarone was given to rats by intragastric and intravenous administration, respectively, while neferine was co-administratered by intragastric administration. Blood samples were collected from the orbital venous plexus at indicated time points and were analyzed for amiodarone concentration using RP-HPLC. The geometric mean ratio for C(max) and AUC(0-96) was calculated. There were no significant differences between the pharmacokinetics parameters of amiodarone administered intravenously or intragastrically and the control (without neferine) group (with ratios of 0.7-1.4 in all experimental groups), suggesting that neferine had no effect on amiodarone plasma pharmacokinetics. The dosage regimen of amiodarone does not need to be taken into consideration when combined with neferine. Copyright (C) 2010 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000292601500002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60764
专题北京大学第二临床医学院_药剂科
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pharmacol, Wuhan 430074, Peoples R China
2.Beijing Univ, Peoples Hosp, Dept Pharm, Beijing 100871, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Epidemiol, Wuhan 430074, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Hlth Stat, Wuhan 430074, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Integrated TCM & Western Med Hosp, Dept Pharm, Wuhan 430074, Peoples R China
推荐引用方式
GB/T 7714
Wan, Jiadao,Zhao, Libo,Xu, Chuan,et al. Effects of neferine on the pharmacokinetics of amiodarone in rats[J]. BIOMEDICAL CHROMATOGRAPHY,2011,25(8):858-866.
APA Wan, Jiadao.,Zhao, Libo.,Xu, Chuan.,Zhang, Shaohui.,Zhang, Zhixin.,...&Wang, Jialing.(2011).Effects of neferine on the pharmacokinetics of amiodarone in rats.BIOMEDICAL CHROMATOGRAPHY,25(8),858-866.
MLA Wan, Jiadao,et al."Effects of neferine on the pharmacokinetics of amiodarone in rats".BIOMEDICAL CHROMATOGRAPHY 25.8(2011):858-866.
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