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学科主题: 临床医学
题名:
Effects of neferine on the pharmacokinetics of amiodarone in rats
作者: Wan, Jiadao1; Zhao, Libo2; Xu, Chuan3,4; Zhang, Shaohui5; Zhang, Zhixin1; Zeng, Cheng1; Chang, Mujun1; Xiao, Junhua1; Wang, Jialing1
关键词: amiodarone ; neferine ; pharmacokinetic interaction ; RP-HPLC ; cytochrome P450
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2011-08-01
DOI: 10.1002/bmc.1535
卷: 25, 期:8, 页:858-866
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: INDUCED PULMONARY-FIBROSIS ; ATRIAL-FIBRILLATION ; PREVENTION ; THERAPY ; ISOLIENSININE ; PIRFENIDONE ; DRONEDARONE ; WARFARIN ; CELLS
英文摘要:

Amiodarone, an iodinated benzofuran derivative with predominantly class III anti-arrhythmic effects, is used to treat supraventricular and ventricular arrhythmias. The purpose of this study was to assess the potential of neferine, an effective anti-pulmonary fibrosis drug isolated from the embryo of Nelumbo nucifera Gaertner′s seeds, to alter the pharmacokinetic profile of amiodarone. Experimental Sprague-Dawley rats were randomly divided into two groups. In groups 1 and 2, amiodarone was given to rats by intragastric and intravenous administration, respectively, while neferine was co-administratered by intragastric administration. Blood samples were collected from the orbital venous plexus at indicated time points and were analyzed for amiodarone concentration using RP-HPLC. The geometric mean ratio for C(max) and AUC(0-96) was calculated. There were no significant differences between the pharmacokinetics parameters of amiodarone administered intravenously or intragastrically and the control (without neferine) group (with ratios of 0.7-1.4 in all experimental groups), suggesting that neferine had no effect on amiodarone plasma pharmacokinetics. The dosage regimen of amiodarone does not need to be taken into consideration when combined with neferine. Copyright (C) 2010 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000292601500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60764
Appears in Collections:北京大学第二临床医学院_药剂科_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pharmacol, Wuhan 430074, Peoples R China
2.Beijing Univ, Peoples Hosp, Dept Pharm, Beijing 100871, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Epidemiol, Wuhan 430074, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Hlth Stat, Wuhan 430074, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Integrated TCM & Western Med Hosp, Dept Pharm, Wuhan 430074, Peoples R China

Recommended Citation:
Wan, Jiadao,Zhao, Libo,Xu, Chuan,et al. Effects of neferine on the pharmacokinetics of amiodarone in rats[J]. BIOMEDICAL CHROMATOGRAPHY,2011,25(8):858-866.
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