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学科主题: 基础医学
题名:
Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients
作者: Zhu, WF; Yin, LM; Li, P; Huang, L; Zhuang, H
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2003-08-01
卷: 9, 期:8, 页:1739-1742
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INFECTION ; PREVALENCE ; C/HGV ; HGV ; EPIDEMIOLOGY ; DISEASES ; BIOLOGY ; LIVER
英文摘要:

AIM: To determine the pathogenicity of GB virus C (GBV-C) on liver and the effects of its co-infection on the clinical features and prognosis of patients with hepatitis B and C.

METHODS: Cross-sectional study was carried out in 413 patients with acute, chronic hepatitis B or liver cirrhosis, and in 67 hemodialysis patients. A 20-month prospective cohort study was carried out in 95 hepatitis B and 80 hepatitis C patients. A reverse transcriptase nested polymerase chain reaction (RT-nPCR) of the 5-noncoding region was used to detect circulating GBV-C RNA. Liver function was determined by an automated analyzer for all patients.

RESULTS: The prevalence of GBV-C in the high-risk populations with the virus transmitted via blood was high, ranging from 16.2 to 28.8 %. Co-infection with GBV-C in hepatitis B patients did not affect the clinical features of the disease or liver function. The dialysis patients infected with GBV-C alone did not develop functional changes to the liver. Prospective cohort study showed that GBV-C co-infection did not affect the clinical features, prognosis or negative serum conversion rate of chronic hepatitis B and C.

CONCLUSION: The results suggest that GBV-C has no marked pathogenicity on liver, so it may not be a hepatitis virus.

语种: 英语
WOS记录号: WOS:000184963600018
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60765
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: Beijing Univ, Sch Basic Med Sci, Dept Microbiol, Beijing 100083, Peoples R China

Recommended Citation:
Zhu, WF,Yin, LM,Li, P,et al. Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(8):1739-1742.
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