北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients
作者: Zhu, WF; Yin, LM; Li, P; Huang, L; Zhuang, H
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2003-08-01
卷: 9, 期:8, 页:1739-1742
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INFECTION ; PREVALENCE ; C/HGV ; HGV ; EPIDEMIOLOGY ; DISEASES ; BIOLOGY ; LIVER
英文摘要:

AIM: To determine the pathogenicity of GB virus C (GBV-C) on liver and the effects of its co-infection on the clinical features and prognosis of patients with hepatitis B and C.

METHODS: Cross-sectional study was carried out in 413 patients with acute, chronic hepatitis B or liver cirrhosis, and in 67 hemodialysis patients. A 20-month prospective cohort study was carried out in 95 hepatitis B and 80 hepatitis C patients. A reverse transcriptase nested polymerase chain reaction (RT-nPCR) of the 5-noncoding region was used to detect circulating GBV-C RNA. Liver function was determined by an automated analyzer for all patients.

RESULTS: The prevalence of GBV-C in the high-risk populations with the virus transmitted via blood was high, ranging from 16.2 to 28.8 %. Co-infection with GBV-C in hepatitis B patients did not affect the clinical features of the disease or liver function. The dialysis patients infected with GBV-C alone did not develop functional changes to the liver. Prospective cohort study showed that GBV-C co-infection did not affect the clinical features, prognosis or negative serum conversion rate of chronic hepatitis B and C.

CONCLUSION: The results suggest that GBV-C has no marked pathogenicity on liver, so it may not be a hepatitis virus.

语种: 英语
WOS记录号: WOS:000184963600018
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60765
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients.pdf(93KB)期刊论文出版稿限制开放 联系获取全文

作者单位: Beijing Univ, Sch Basic Med Sci, Dept Microbiol, Beijing 100083, Peoples R China

Recommended Citation:
Zhu, WF,Yin, LM,Li, P,et al. Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(8):1739-1742.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhu, WF]'s Articles
[Yin, LM]'s Articles
[Li, P]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhu, WF]‘s Articles
[Yin, LM]‘s Articles
[Li, P]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace