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Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury
Yin, Xiao Feng; Fu, Zhong Guo; Zhang, Dian Yin; Jiang, Bao Guo
关键词ATP-sensitive potassium channel mRNA expression dorsal root ganglion spinal cord cerebral cortex
刊名EUROPEAN NEUROLOGY
2007
DOI10.1159/000097003
57期:1页:4-10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NEURITE GROWTH-INHIBITORS ; PROMOTE AXONAL REGENERATION ; ADULT-RATS ; CORTICOSPINAL TRACT ; FUNCTIONAL RECOVERY ; K+ CHANNEL ; KIR6.2 SUBUNIT ; TRANSPLANTS ; NEURONS ; STOICHIOMETRY
英文摘要

ATP-sensitive potassium channels (K-ATP) are involved in the regulation of potassium homeostasis in the nervous system, and they may play an important role in acute peripheral nerve and spinal cord injury. Here, the expression of the K-ATP genes was monitored by reverse transcription polymerase chain reaction (RT-PCR) in the rat dorsal root ganglion, spinal cord and cerebral cortex following acute sciatic nerve and spinal cord injury. Electrophoresis of the RT-PCR products showed that in comparison with the normal rats, the K-ATP mRNA expression level was up-regulated for the Kir6.2 subunit in the rat dorsal root ganglion 4 and 24 h after the acute sciatic nerve injury ( 142.7 +/- 8 23.0 and 135.5 +/- 21.0%, p < 0.05, vs. control, n = 3), and both Kir6.1 and sulphonylurea receptor 2 mRNA were increased in the spinal cord during the same time period after the acute spinal cord injury (266.5 +/- 67.1 and 248.7 +/- 67.7%; 145.1 +/- 42.6 and 152.6 +/- 44.3%, p < 0.05, vs. control, n = 3). No significant changes of K-ATP genes were observed in the cerebral cortex among both sciatic-nerve-and spinal-cord-injured animals. These results suggest that acute peripheral nerve and spinal cord injury provoke different regulations of K-ATP gene expression in the peripheral and central nervous system. Copyright (c) 2007 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000243064800002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60766
专题北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Dept Orthopaed & Trauma, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Yin, Xiao Feng,Fu, Zhong Guo,Zhang, Dian Yin,et al. Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury[J]. EUROPEAN NEUROLOGY,2007,57(1):4-10.
APA Yin, Xiao Feng,Fu, Zhong Guo,Zhang, Dian Yin,&Jiang, Bao Guo.(2007).Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury.EUROPEAN NEUROLOGY,57(1),4-10.
MLA Yin, Xiao Feng,et al."Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury".EUROPEAN NEUROLOGY 57.1(2007):4-10.
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