北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury
作者: Yin, Xiao Feng; Fu, Zhong Guo; Zhang, Dian Yin; Jiang, Bao Guo
关键词: ATP-sensitive potassium channel ; mRNA expression ; dorsal root ganglion ; spinal cord ; cerebral cortex
刊名: EUROPEAN NEUROLOGY
发表日期: 2007
DOI: 10.1159/000097003
卷: 57, 期:1, 页:4-10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NEURITE GROWTH-INHIBITORS ; PROMOTE AXONAL REGENERATION ; ADULT-RATS ; CORTICOSPINAL TRACT ; FUNCTIONAL RECOVERY ; K+ CHANNEL ; KIR6.2 SUBUNIT ; TRANSPLANTS ; NEURONS ; STOICHIOMETRY
英文摘要:

ATP-sensitive potassium channels (K-ATP) are involved in the regulation of potassium homeostasis in the nervous system, and they may play an important role in acute peripheral nerve and spinal cord injury. Here, the expression of the K-ATP genes was monitored by reverse transcription polymerase chain reaction (RT-PCR) in the rat dorsal root ganglion, spinal cord and cerebral cortex following acute sciatic nerve and spinal cord injury. Electrophoresis of the RT-PCR products showed that in comparison with the normal rats, the K-ATP mRNA expression level was up-regulated for the Kir6.2 subunit in the rat dorsal root ganglion 4 and 24 h after the acute sciatic nerve injury ( 142.7 +/- 8 23.0 and 135.5 +/- 21.0%, p < 0.05, vs. control, n = 3), and both Kir6.1 and sulphonylurea receptor 2 mRNA were increased in the spinal cord during the same time period after the acute spinal cord injury (266.5 +/- 67.1 and 248.7 +/- 67.7%; 145.1 +/- 42.6 and 152.6 +/- 44.3%, p < 0.05, vs. control, n = 3). No significant changes of K-ATP genes were observed in the cerebral cortex among both sciatic-nerve-and spinal-cord-injured animals. These results suggest that acute peripheral nerve and spinal cord injury provoke different regulations of K-ATP gene expression in the peripheral and central nervous system. Copyright (c) 2007 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000243064800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60766
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Dept Orthopaed & Trauma, Beijing 100044, Peoples R China

Recommended Citation:
Yin, Xiao Feng,Fu, Zhong Guo,Zhang, Dian Yin,et al. Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury[J]. EUROPEAN NEUROLOGY,2007,57(1):4-10.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yin, Xiao Feng]'s Articles
[Fu, Zhong Guo]'s Articles
[Zhang, Dian Yin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yin, Xiao Feng]‘s Articles
[Fu, Zhong Guo]‘s Articles
[Zhang, Dian Yin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace