北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 消化科  > 期刊论文
学科主题: 临床医学
题名:
Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma
作者: Gao, Chun1,2; Wang, Ai-Ying1
关键词: small intestine ; adenocarcinoma ; apoptosis ; Bax ; Bax/Bcl-2 ratio
刊名: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
发表日期: 2009-12-01
DOI: 10.1369/jhc.2009.954446
卷: 57, 期:12, 页:1139-1148
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: COLORECTAL-CANCER ; CELL-SURVIVAL ; BCL-2 ; DISEASE ; CHEMOTHERAPY ; COEXPRESSION ; CARCINOMA ; DEATH
英文摘要:

Human small intestine accounts for 75% of the gastrointestinal (GI) length but for only 1-5% of GI tumors. The reason remains as yet unclearly understood. our study was designed to examine whether increased apoptosis and expression of related genes/proteins, especially those of the Bcl-2 family, contribute to this difference. For this purpose, 77 samples from patients were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and immunohistochemistry, including 40 cases from normal small intestine (jejunum), 7 cases from jejunum and ileum adenocarcinomas, and 30 cases from normal colon. The results showed that a significantly higher level of enterocyte apoptosis was observed in normal small intestine compared with small intestinal adenocarcinomas and normal colon (median of apoptotic index, 15.2% vs 0.1% and 1.6%, p<0.01). A similar pattern was observed for Bax (expression-positive, 77.5% vs 28.6% and 53.3%, p<0.05) but not for Bcl-2 (42.5% vs 42.9% and 46.7%, p>0.05) or Bax/Bcl-2 ratio (percent of samples having a ratio >= 1, 45.0% vs 14.3% and 36.7%, p>0.05). In conclusion, increased apoptosis and expression of Bax, not Bcl-2 or the Bax/Bcl-2 ratio, may play some role in the relatively lower incidence of human small intestinal carcinomas. However, more studies are required for a better understanding of these changes. (J Histochem Cytochem 57:1139-1148, 2009)

语种: 英语
所属项目编号: 30571810
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000271845800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60768
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Dept Gastroenterol, Beijing, Peoples R China

Recommended Citation:
Gao, Chun,Wang, Ai-Ying. Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma[J]. JOURNAL OF HISTOCHEMISTRY &amp; CYTOCHEMISTRY,2009,57(12):1139-1148.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, Chun]'s Articles
[Wang, Ai-Ying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, Chun]‘s Articles
[Wang, Ai-Ying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace