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学科主题临床医学
Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma
Gao, Chun1,2; Wang, Ai-Ying1
关键词small intestine adenocarcinoma apoptosis Bax Bax/Bcl-2 ratio
刊名JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
2009-12-01
DOI10.1369/jhc.2009.954446
57期:12页:1139-1148
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]COLORECTAL-CANCER ; CELL-SURVIVAL ; BCL-2 ; DISEASE ; CHEMOTHERAPY ; COEXPRESSION ; CARCINOMA ; DEATH
英文摘要

Human small intestine accounts for 75% of the gastrointestinal (GI) length but for only 1-5% of GI tumors. The reason remains as yet unclearly understood. our study was designed to examine whether increased apoptosis and expression of related genes/proteins, especially those of the Bcl-2 family, contribute to this difference. For this purpose, 77 samples from patients were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and immunohistochemistry, including 40 cases from normal small intestine (jejunum), 7 cases from jejunum and ileum adenocarcinomas, and 30 cases from normal colon. The results showed that a significantly higher level of enterocyte apoptosis was observed in normal small intestine compared with small intestinal adenocarcinomas and normal colon (median of apoptotic index, 15.2% vs 0.1% and 1.6%, p<0.01). A similar pattern was observed for Bax (expression-positive, 77.5% vs 28.6% and 53.3%, p<0.05) but not for Bcl-2 (42.5% vs 42.9% and 46.7%, p>0.05) or Bax/Bcl-2 ratio (percent of samples having a ratio >= 1, 45.0% vs 14.3% and 36.7%, p>0.05). In conclusion, increased apoptosis and expression of Bax, not Bcl-2 or the Bax/Bcl-2 ratio, may play some role in the relatively lower incidence of human small intestinal carcinomas. However, more studies are required for a better understanding of these changes. (J Histochem Cytochem 57:1139-1148, 2009)

语种英语
WOS记录号WOS:000271845800006
项目编号30571810
资助机构National Natural Science Foundation of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60768
专题北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Dept Gastroenterol, Beijing, Peoples R China
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GB/T 7714
Gao, Chun,Wang, Ai-Ying. Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma[J]. JOURNAL OF HISTOCHEMISTRY &amp; CYTOCHEMISTRY,2009,57(12):1139-1148.
APA Gao, Chun,&Wang, Ai-Ying.(2009).Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma.JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY,57(12),1139-1148.
MLA Gao, Chun,et al."Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma".JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 57.12(2009):1139-1148.
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