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学科主题: 临床医学
题名:
Roles of ER beta and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen
作者: Huang, Weiren1,2; Chen, Yuanbin1,3,4; Liu, Yuchen2,5; Zhang, Qiaoxia2; Yu, Zhou1,6; Mou, Lisha1,2; Wu, Hanwei1; Zhao, Li1; Long, Ting3; Qin, Danian3; Gui, Yaoting1
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2015
DOI: 10.1155/2015/251780
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: COUPLED RECEPTOR GPR30 ; ANDROGEN RECEPTOR ; PROSTATE-CANCER ; OVARIAN-CANCER ; UP-REGULATION ; ACTIVATION ; EXPRESSION ; ALPHA ; 17-BETA-ESTRADIOL ; APOPTOSIS
英文摘要:

Bladder cancer belongs to one of the most common cancers and is a leading cause of deaths in our society. Urothelial carcinoma of the bladder (UCB) is the main type of this cancer, and the estrogen receptors in UCB remain to be studied. Our experiment aimed to investigate the possible biological effect of 17 beta-estradiol on human bladder-derived T24 carcinoma cells and to indicate its related mechanisms. T24 cells were treated with various doses of 17 beta-estradiol, and cell proliferation was detected using MTT assays. 17 beta-estradiol promoted T24 cell proliferation independent of ER beta/GPR30-regulated EGFR-MAPK pathway, while it inhibited cell growth via GPR30. Furthermore, the expression levels of downstream genes (c-FOS, BCL-2, and CYCLIN D1) were increased by 17 beta-estradiol and this effect was independently associated with activity of the EGFR-MAPK pathway. The two estrogen receptors might be potential therapeutic targets for the treatment of bladder cancer.

语种: 英语
所属项目编号: 2014CB745201 ; 81100460 ; 81270686 ; 31271244 ; 201202055 ; 201202057 ; S2012010008200 ; JCYJ20120614155650545
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Science and Technology Program of Shenzhen ; Guangdong Natural Science Foundation ; Basic Research Program of Shenzhen
WOS记录号: WOS:000355432200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60770
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Jiaying Univ, Coll Med, Dept Physiol, Meizhou 514031, Peoples R China
2.Anhui Med Univ, Hefei 230032, Peoples R China
3.Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr,Inst Urol, Guangdong & Shenzhen Key Lab Male Reprod Med & G, Shenzhen 518036, Peoples R China
4.Shenzhen Univ, Affiliated Hosp 1, Key Lab Med Reprogramming Technol, Shenzhen Peoples Hosp 2, Shenzhen 518035, Peoples R China
5.Shantou Univ, Sch Med, Dept Physiol, Shantou 515031, Peoples R China
6.Fourth Mil Med Univ, Inst Plast Surg, Xijing Hosp, Xian 710032, Peoples R China

Recommended Citation:
Huang, Weiren,Chen, Yuanbin,Liu, Yuchen,et al. Roles of ER beta and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen[J]. BIOMED RESEARCH INTERNATIONAL,2015.
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