|Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats|
|Lou, Li-Xia1; Geng, Bin1; Du, Jun-Bao3,4; Tang, Chao-Shu1,2|
|关键词||endoplasmic reticulum stress hydrogen sulphide induced hypothermia rats stress gastric ulcer|
|刊名||CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Pharmacology & Pharmacy ; Physiology|
|研究领域[WOS]||Pharmacology & Pharmacy ; Physiology|
|关键词[WOS]||ENDOPLASMIC-RETICULUM STRESS ; PITUITARY-ADRENAL AXIS ; ANIMATION-LIKE STATE ; LIPID-PEROXIDATION ; H2S ; INJURY ; APOPTOSIS ; BRAIN ; LIVER ; ASSAY|
1. Hydrogen sulphide (H2S) acts as a gaseous cellular messenger and has recently been reported to induce a suspended animation-like state in mice. The aim of the present study was to investigate the protective role of H2S exposure in stress gastric ulcer.
2. In the present study, we used a rat model of water immersion and restraint stress (WRS) to induce the typical stress disease, namely stress gastric ulcer. Rats were treated with WRS for 4 h, with or without pre-exposure to H2S (160 p.p.m. H2S for 2.5 h).
3. In H2S-exposed rats, body temperature was significantly reduced by 2.5C (P < 0.01) and oxygen consumption was reduced by 37.1% (P < 0.01) compared with control rats. Plasma levels of H2S were increased by 20.8% (P < 0.01) following pre-exposure. Pre-exposure to H2S significantly reduced the gastric ulcer index, from 24 +/- 9 to 9 +/- 2 (P < 0.01), in WRS rats. In addition, WRS increased plasma levels of adrenocorticotropin (ACTH) and corticosterone 4.7- and 4.8-fold, respectively (both P < 0.01). Pre-exposure to H2S markedly suppressed plasma ACTH and corticosterone level by 34.4 and 53.2%, respectively (both P < 0.01), and reduced WRS-elevated myeloperoxidase (MPO) activity by 19%. In the present study, WRS increased gastric malondialdehyde and conjugated diene content by 42 and 68%, respectively (both P < 0.01), and H2S exposure reduced lipid peroxide production. Finally, H2S exposure inhibited the WRS-elevated expression of glucose-regulated protein 78 and caspase 12, markers of endoplasmic reticulum stress.
4. In conclusion, a low concentration of H2S may be a new pharmacological tool for induced hypothermia to prevent severe stress-induced diseases and multifarious trauma in the clinical setting.
|作者单位||1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
4.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
|Lou, Li-Xia,Geng, Bin,Du, Jun-Bao,et al. Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2008,35(2):223-228.|
|APA||Lou, Li-Xia,Geng, Bin,Du, Jun-Bao,&Tang, Chao-Shu.(2008).Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,35(2),223-228.|
|MLA||Lou, Li-Xia,et al."Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 35.2(2008):223-228.|
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