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学科主题: 临床医学
题名:
Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats
作者: Lou, Li-Xia1; Geng, Bin1; Du, Jun-Bao3,4; Tang, Chao-Shu1,2
关键词: endoplasmic reticulum stress ; hydrogen sulphide ; induced hypothermia ; rats ; stress gastric ulcer
刊名: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
发表日期: 2008-02-01
DOI: 10.1111/j.1440-1681.2007.04812.x
卷: 35, 期:2, 页:223-228
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Physiology
研究领域[WOS]: Pharmacology & Pharmacy ; Physiology
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; PITUITARY-ADRENAL AXIS ; ANIMATION-LIKE STATE ; LIPID-PEROXIDATION ; H2S ; INJURY ; APOPTOSIS ; BRAIN ; LIVER ; ASSAY
英文摘要:

1. Hydrogen sulphide (H2S) acts as a gaseous cellular messenger and has recently been reported to induce a suspended animation-like state in mice. The aim of the present study was to investigate the protective role of H2S exposure in stress gastric ulcer.

2. In the present study, we used a rat model of water immersion and restraint stress (WRS) to induce the typical stress disease, namely stress gastric ulcer. Rats were treated with WRS for 4 h, with or without pre-exposure to H2S (160 p.p.m. H2S for 2.5 h).

3. In H2S-exposed rats, body temperature was significantly reduced by 2.5C (P < 0.01) and oxygen consumption was reduced by 37.1% (P < 0.01) compared with control rats. Plasma levels of H2S were increased by 20.8% (P < 0.01) following pre-exposure. Pre-exposure to H2S significantly reduced the gastric ulcer index, from 24 +/- 9 to 9 +/- 2 (P < 0.01), in WRS rats. In addition, WRS increased plasma levels of adrenocorticotropin (ACTH) and corticosterone 4.7- and 4.8-fold, respectively (both P < 0.01). Pre-exposure to H2S markedly suppressed plasma ACTH and corticosterone level by 34.4 and 53.2%, respectively (both P < 0.01), and reduced WRS-elevated myeloperoxidase (MPO) activity by 19%. In the present study, WRS increased gastric malondialdehyde and conjugated diene content by 42 and 68%, respectively (both P < 0.01), and H2S exposure reduced lipid peroxide production. Finally, H2S exposure inhibited the WRS-elevated expression of glucose-regulated protein 78 and caspase 12, markers of endoplasmic reticulum stress.

4. In conclusion, a low concentration of H2S may be a new pharmacological tool for induced hypothermia to prevent severe stress-induced diseases and multifarious trauma in the clinical setting.

语种: 英语
WOS记录号: WOS:000252259300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60775
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
4.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China

Recommended Citation:
Lou, Li-Xia,Geng, Bin,Du, Jun-Bao,et al. Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2008,35(2):223-228.
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