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学科主题临床医学
Retinal coenzyme Q in the bovine eye
Qu, Jinfeng1,2; Ma, Li1; Washington, Ilyas1
关键词lipid retina coenzyme Q outer segments ubiquinol
刊名BIOFACTORS
2011-09-01
DOI10.1002/biof.166
37期:5页:393-398
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]OUTER SEGMENT DISKS ; AGE-RELATED-CHANGES ; ALPHA-TOCOPHEROL ; VITAMIN-E ; CYTOCHEMICAL-LOCALIZATION ; MACULAR DEGENERATION ; LIPID COMPOSITIONS ; HUMAN-TISSUES ; REDOX STATE ; UBIQUINONE
英文摘要

Coenzyme Q plays an integral role in oxygen metabolism and management, and there is a positive correlation between low tissue coenzyme Q concentrations and the progression of many degenerative diseases. Retinal oxidative damage plays a role in the pathogenesis of many degenerative eye diseases; nevertheless, despite the retina′s high rate of oxygen metabolism, there is little data relating to retinal coenzyme Q concentrations. In this study, we quantified coenzyme Q in the model bovine eye and determined whether it could function as a retinal lipid antioxidant. We found that the neural retina′s ubiquinone concentration exceeded those of the vitreous humor, lens, choroid, and extraocular muscle, but it was lower than those measured in heart, kidney, liver, and brain tissues. Ubiquinol was found to be as effective as vitamin E as a retinal lipid antioxidant. The overall relatively low levels of ubiquinone found in the retina, coupled with the retina′s need for lipid antioxidants and oxidative metabolism, suggests that retinal function might be sensitive to changes in ubiquinone concentrations.

语种英语
WOS记录号WOS:000296478600009
资助机构Mebane Charitable Foundation
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60778
专题北京大学第二临床医学院_眼科
作者单位1.Columbia Univ, Dept Ophthalmol, Med Ctr, New York, NY 10032 USA
2.Peking Univ, People Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Qu, Jinfeng,Ma, Li,Washington, Ilyas. Retinal coenzyme Q in the bovine eye[J]. BIOFACTORS,2011,37(5):393-398.
APA Qu, Jinfeng,Ma, Li,&Washington, Ilyas.(2011).Retinal coenzyme Q in the bovine eye.BIOFACTORS,37(5),393-398.
MLA Qu, Jinfeng,et al."Retinal coenzyme Q in the bovine eye".BIOFACTORS 37.5(2011):393-398.
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