IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice
Yang, Ruiyue1,2,3; Wang, Junbo1; Liu, Zhigang1; Pei, Xinrong1; Han, Xiaolong1; Li, Yong1
关键词bioactive peptide GSH-Px MDA radioprotective SOD
刊名MARINE DRUGS
2011-11-01
DOI10.3390/md9112304
9期:11页:2304-2315
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]BIOACTIVE PEPTIDES ; ETHANOLIC EXTRACT ; IRRADIATION ; FOOD ; POLYSACCHARIDES ; ASSOCIATION ; FRACTIONS ; PROTEIN ; CANCER ; RATS
英文摘要

Marine oligopeptide preparation (MOP) obtained from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, has been found to possess a radioprotective property through stimulation of the radiation-induced immunosuppression. The current study aimed to further investigate the free radicals scavenging and antioxidant effects of MOP in radiation injured mice. Female ICR mice (6-8 weeks old) were randomly divided into 5 groups, i.e., blank control, irradiation control and MOP (0.225, 0.450 and 1.350 g/kg body weight) plus an irradiation-treated group. The result revealed that MOP significantly increased the white blood cell counts after irradiation, and lessened the radiation-induced oxidative damage. These effects may be caused by augmentation of the activities of antioxidant enzymes, such as SOD and GSH-Px, reduction of the lipid peroxidation (MDA level) in liver, and protection against radiation-induced apoptosis. Therefore, we propose that MOP be used as an ideal antioxidant to alleviate radiation-induced oxidation damage in cancer patients.

语种英语
WOS记录号WOS:000298929200010
项目编号2006BAD27B08
资助机构foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60780
专题北京大学公共卫生学院
作者单位1.Minist Hlth, Beijing Inst Geriatr, Beijing 100730, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
3.Minist Hlth, Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Yang, Ruiyue,Wang, Junbo,Liu, Zhigang,et al. Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice[J]. MARINE DRUGS,2011,9(11):2304-2315.
APA Yang, Ruiyue,Wang, Junbo,Liu, Zhigang,Pei, Xinrong,Han, Xiaolong,&Li, Yong.(2011).Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice.MARINE DRUGS,9(11),2304-2315.
MLA Yang, Ruiyue,et al."Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice".MARINE DRUGS 9.11(2011):2304-2315.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Ruiyue]的文章
[Wang, Junbo]的文章
[Liu, Zhigang]的文章
百度学术
百度学术中相似的文章
[Yang, Ruiyue]的文章
[Wang, Junbo]的文章
[Liu, Zhigang]的文章
必应学术
必应学术中相似的文章
[Yang, Ruiyue]的文章
[Wang, Junbo]的文章
[Liu, Zhigang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。