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学科主题: 公共卫生
题名:
Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice
作者: Yang, Ruiyue1,2,3; Wang, Junbo1; Liu, Zhigang1; Pei, Xinrong1; Han, Xiaolong1; Li, Yong1
关键词: bioactive peptide ; GSH-Px ; MDA ; radioprotective ; SOD
刊名: MARINE DRUGS
发表日期: 2011-11-01
DOI: 10.3390/md9112304
卷: 9, 期:11, 页:2304-2315
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: BIOACTIVE PEPTIDES ; ETHANOLIC EXTRACT ; IRRADIATION ; FOOD ; POLYSACCHARIDES ; ASSOCIATION ; FRACTIONS ; PROTEIN ; CANCER ; RATS
英文摘要:

Marine oligopeptide preparation (MOP) obtained from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, has been found to possess a radioprotective property through stimulation of the radiation-induced immunosuppression. The current study aimed to further investigate the free radicals scavenging and antioxidant effects of MOP in radiation injured mice. Female ICR mice (6-8 weeks old) were randomly divided into 5 groups, i.e., blank control, irradiation control and MOP (0.225, 0.450 and 1.350 g/kg body weight) plus an irradiation-treated group. The result revealed that MOP significantly increased the white blood cell counts after irradiation, and lessened the radiation-induced oxidative damage. These effects may be caused by augmentation of the activities of antioxidant enzymes, such as SOD and GSH-Px, reduction of the lipid peroxidation (MDA level) in liver, and protection against radiation-induced apoptosis. Therefore, we propose that MOP be used as an ideal antioxidant to alleviate radiation-induced oxidation damage in cancer patients.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000298929200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60780
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Minist Hlth, Beijing Inst Geriatr, Beijing 100730, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
3.Minist Hlth, Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China

Recommended Citation:
Yang, Ruiyue,Wang, Junbo,Liu, Zhigang,et al. Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice[J]. MARINE DRUGS,2011,9(11):2304-2315.
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