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Magnolol derivative 002C-3 protects brain against ischemia-reperfusion injury via inhibiting apoptosis and autophagy
Li, Hongfei1; Liu, Xiaoyan1; Zhu, Yuanjun1; Liu, Ye2; Wang, Yinye1
关键词002C-3 Cerebral ischemia-reperfusion Apoptosis Autophagy
刊名NEUROSCIENCE LETTERS
2015-02-19
DOI10.1016/j.neulet.2015.01.007
588页:178-183
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]FOCAL CEREBRAL-ISCHEMIA ; CELL-DEATH ; STROKE ; HONOKIOL ; RATS ; EXPRESSION ; OCCLUSION ; FUTURE
英文摘要

Neuroprotective agents can rescue ischemic penumbra in cerebral ischemia. However, the clinically effective neuroprotective agents for cerebral ischemic injury remain deficient in clinic so far. This study was undertaken to investigate the brain protective effect of 002C-3 and its potential mechanisms in rats, and its preliminary toxicity in mice. A transient middle cerebral artery occlusion (tMCAO) model in rats was used to evaluate its effect and mechanism, a dose limited experiment was used to evaluate its preliminary toxicity. 10-50 mu g/kg of 002C-3 (single iv bolus after reperfusion) significantly reduced neurological scores, infarct volumes and brain water contents, and the effect was more potent than that of magnolol under the same mole dose; 50 mu g/kg of 002C-3 significantly decreased the number of TUNEL-positive cells, reduced the activity of caspase-3, and lowered the autophagy-related proteins LC3-II and Beclin-1 level in cerebral tissue. At 1000 times dose of high effective dose (ip) 002C-3 failed to show evident toxicity in mice, and the mean body weight of mice treated with 002C-3 was almost the same as that of the vehicle control, but magnolol caused evident toxicity and death. In conclusion, 002C-3 has significant protective effect against cerebral ischemia-reperfusion injury; the effect is more potent than magnolol; this effect is maybe associated with its inhibition of both apoptosis and autophagy; its toxicity is greatly reduced compared to magnolol. These results provided data for its further research and development. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000350922300032
项目编号61071002
资助机构Natural Science Foundation of China ; Beijing Honghui New Medical Technology Co., Ltd.
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60782
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Beijing Honghui New Med Technol Co Ltd, Beijing Daxing Biol Med Ind Base, Beijing 102600, Peoples R China
推荐引用方式
GB/T 7714
Li, Hongfei,Liu, Xiaoyan,Zhu, Yuanjun,et al. Magnolol derivative 002C-3 protects brain against ischemia-reperfusion injury via inhibiting apoptosis and autophagy[J]. NEUROSCIENCE LETTERS,2015,588:178-183.
APA Li, Hongfei,Liu, Xiaoyan,Zhu, Yuanjun,Liu, Ye,&Wang, Yinye.(2015).Magnolol derivative 002C-3 protects brain against ischemia-reperfusion injury via inhibiting apoptosis and autophagy.NEUROSCIENCE LETTERS,588,178-183.
MLA Li, Hongfei,et al."Magnolol derivative 002C-3 protects brain against ischemia-reperfusion injury via inhibiting apoptosis and autophagy".NEUROSCIENCE LETTERS 588(2015):178-183.
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