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学科主题: 口腔医学
题名:
Nimotuzumab suppresses epithelial-mesenchymal transition and enhances apoptosis in low-dose UV-C treated salivary adenoid cystic carcinoma cell lines in vitro
作者: Jiang, Yang1; Ge, Xi-Yuan2; Liu, Shu-Ming1; Zheng, Lei1; Huang, Ming-Wei1; Shi, Yan1; Fu, Jia2; Zhang, Jian-Guo1; Li, Sheng-Lin2
关键词: epidermal growth factor receptor ; epithelial-mesenchymal transition ; Nimotuzumab ; salivary adenoid cystic carcinoma ; ultraviolet-C
刊名: ANTI-CANCER DRUGS
发表日期: 2014-10-01
DOI: 10.1097/CAD.0000000000000139
卷: 25, 期:9, 页:1052-1060
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pharmacology & Pharmacy
研究领域[WOS]: Oncology ; Pharmacology & Pharmacy
关键词[WOS]: EPIDERMAL-GROWTH-FACTOR ; PANCREATIC-CANCER CELLS ; HUMAN IMMUNE-SYSTEM ; FACTOR RECEPTOR ; ULTRAVIOLET-RADIATION ; MOLECULAR-MECHANISMS ; EGFR ; METASTASIS ; ANTIBODY ; IRRADIATION
英文摘要:

Salivary adenoid cystic carcinoma (SACC), which is one of the most common malignant tumors of the salivary glands, is associated with a poor long-term outcome. There are currently few therapeutic options for patients with SACC. Recent studies have shown the potential of the application of ultraviolet-C (UV-C) irradiation for the treatment of human cancer. In the present study, we investigated the effects of UV-C in the SACC cell lines SACC-83 and SACC-LM. High-dose UV-C (200 J/m(2)) induced apoptosis and inhibited colony formation significantly. However, low-dose UV-C (10 J/m(2)), which had little effect on apoptosis and colony formation, increased the ability of migration in SACC cells accompanied by a decrease in E-cadherin and an increase in vimentin, suggesting the occurrence of epithelial-mesenchymal transition (EMT). Low-dose UV-C (10 J/m(2)) also resulted in upregulation of the phosphorylated forms of epidermal growth factor receptor (EGFR) and Akt (p-EGFR and p-Akt, respectively). Pretreatment with Nimotuzumab, an anti-EGFR monoclonal antibody, reversed the EMT as well as upregulation of p-EGFR/p-Akt induced by UV-C. Moreover, Nimotuzumab enhanced UV-C induced apoptosis and inhibition of colony formation. Our results indicate that EMT exerts a protective effect against apoptosis induced by low-dose UV-C. Thus, the combined application of Nimotuzumab and low-dose UV-C in vitro has an advantageous antitumor effect in SACC compared with the application of UVC alone. Anti-Cancer Drugs 25:1052-1060 (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 81272966 ; 81272967
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000341534700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60783
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Jiang, Yang,Ge, Xi-Yuan,Liu, Shu-Ming,et al. Nimotuzumab suppresses epithelial-mesenchymal transition and enhances apoptosis in low-dose UV-C treated salivary adenoid cystic carcinoma cell lines in vitro[J]. ANTI-CANCER DRUGS,2014,25(9):1052-1060.
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