IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Nimotuzumab suppresses epithelial-mesenchymal transition and enhances apoptosis in low-dose UV-C treated salivary adenoid cystic carcinoma cell lines in vitro
Jiang, Yang1; Ge, Xi-Yuan2; Liu, Shu-Ming1; Zheng, Lei1; Huang, Ming-Wei1; Shi, Yan1; Fu, Jia2; Zhang, Jian-Guo1; Li, Sheng-Lin2
关键词epidermal growth factor receptor epithelial-mesenchymal transition Nimotuzumab salivary adenoid cystic carcinoma ultraviolet-C
刊名ANTI-CANCER DRUGS
2014-10-01
DOI10.1097/CAD.0000000000000139
25期:9页:1052-1060
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Oncology ; Pharmacology & Pharmacy
关键词[WOS]EPIDERMAL-GROWTH-FACTOR ; PANCREATIC-CANCER CELLS ; HUMAN IMMUNE-SYSTEM ; FACTOR RECEPTOR ; ULTRAVIOLET-RADIATION ; MOLECULAR-MECHANISMS ; EGFR ; METASTASIS ; ANTIBODY ; IRRADIATION
英文摘要

Salivary adenoid cystic carcinoma (SACC), which is one of the most common malignant tumors of the salivary glands, is associated with a poor long-term outcome. There are currently few therapeutic options for patients with SACC. Recent studies have shown the potential of the application of ultraviolet-C (UV-C) irradiation for the treatment of human cancer. In the present study, we investigated the effects of UV-C in the SACC cell lines SACC-83 and SACC-LM. High-dose UV-C (200 J/m(2)) induced apoptosis and inhibited colony formation significantly. However, low-dose UV-C (10 J/m(2)), which had little effect on apoptosis and colony formation, increased the ability of migration in SACC cells accompanied by a decrease in E-cadherin and an increase in vimentin, suggesting the occurrence of epithelial-mesenchymal transition (EMT). Low-dose UV-C (10 J/m(2)) also resulted in upregulation of the phosphorylated forms of epidermal growth factor receptor (EGFR) and Akt (p-EGFR and p-Akt, respectively). Pretreatment with Nimotuzumab, an anti-EGFR monoclonal antibody, reversed the EMT as well as upregulation of p-EGFR/p-Akt induced by UV-C. Moreover, Nimotuzumab enhanced UV-C induced apoptosis and inhibition of colony formation. Our results indicate that EMT exerts a protective effect against apoptosis induced by low-dose UV-C. Thus, the combined application of Nimotuzumab and low-dose UV-C in vitro has an advantageous antitumor effect in SACC compared with the application of UVC alone. Anti-Cancer Drugs 25:1052-1060 (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种英语
所属项目编号81272966 ; 81272967
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000341534700009
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60783
专题北京大学口腔医学院
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Yang,Ge, Xi-Yuan,Liu, Shu-Ming,et al. Nimotuzumab suppresses epithelial-mesenchymal transition and enhances apoptosis in low-dose UV-C treated salivary adenoid cystic carcinoma cell lines in vitro[J]. ANTI-CANCER DRUGS,2014,25(9):1052-1060.
APA Jiang, Yang.,Ge, Xi-Yuan.,Liu, Shu-Ming.,Zheng, Lei.,Huang, Ming-Wei.,...&Li, Sheng-Lin.(2014).Nimotuzumab suppresses epithelial-mesenchymal transition and enhances apoptosis in low-dose UV-C treated salivary adenoid cystic carcinoma cell lines in vitro.ANTI-CANCER DRUGS,25(9),1052-1060.
MLA Jiang, Yang,et al."Nimotuzumab suppresses epithelial-mesenchymal transition and enhances apoptosis in low-dose UV-C treated salivary adenoid cystic carcinoma cell lines in vitro".ANTI-CANCER DRUGS 25.9(2014):1052-1060.
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