IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Screening and analysis of hepatocellular carcinoma-associated antigens and their encoding genes
Shi, YY; Wang, HC; Li, Y; Pan, XW; Sun, WS; Chen, WF
关键词CT antigen cDNA expression library HCC SEREX tumor antigen
刊名CHINESE SCIENCE BULLETIN
2003-10-01
DOI10.1360/03wc0192
48期:20页:2192-2195
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]INDUCED BLOCKING FACTOR ; IMMUNE-RESPONSES ; IDENTIFICATION ; PROGESTERONE ; LYMPHOCYTE ; EXPRESSION ; MIGRATION ; NY-ESO-1
英文摘要

Identification of hepatocellular carcinoma-associated tumor antigens is necessary and pivotal for specific immunotherapy in hepatocellular carcinoma (HCC) patients. In the present study, HCC cDNAs are constructed into ZAP cDNA expression library and screened by sera of patients with HCC. The positive clones are DNA sequenced and analyzed by bioinformatics. Thirty-one genes of hepatocellular carcinoma-associated tumor antigens are identified, of which 1 is unknown and 30 are known. The proteins encoded by these known genes can be classified into 8 categories: constitutive molecules of hepatocytes, RNA transcription and splicing-associated molecules, protein metabolism-associated molecules, energy synthesis-associated molecules, signal transduction molecules, cell adhesion molecules, immunosuppressive molecules, and proteins with unknown function. Among these genes, CAGE is a cancer-testis (CT) antigen. It is concluded that identification of hepatocellular carcinoma-associated tumor antigens provides potential targets for immunotherapy of HCC patients and facilitates explanation of carcinogenesis of HCC.

语种英语
WOS记录号WOS:000186305600009
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60789
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Shandong Univ, Dept Immunol, Sch Med, Jinan 250012, Peoples R China
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GB/T 7714
Shi, YY,Wang, HC,Li, Y,et al. Screening and analysis of hepatocellular carcinoma-associated antigens and their encoding genes[J]. CHINESE SCIENCE BULLETIN,2003,48(20):2192-2195.
APA Shi, YY,Wang, HC,Li, Y,Pan, XW,Sun, WS,&Chen, WF.(2003).Screening and analysis of hepatocellular carcinoma-associated antigens and their encoding genes.CHINESE SCIENCE BULLETIN,48(20),2192-2195.
MLA Shi, YY,et al."Screening and analysis of hepatocellular carcinoma-associated antigens and their encoding genes".CHINESE SCIENCE BULLETIN 48.20(2003):2192-2195.
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