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学科主题: 基础医学
题名:
Screening and analysis of hepatocellular carcinoma-associated antigens and their encoding genes
作者: Shi, YY; Wang, HC; Li, Y; Pan, XW; Sun, WS; Chen, WF
关键词: CT antigen ; cDNA expression library ; HCC ; SEREX ; tumor antigen
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2003-10-01
DOI: 10.1360/03wc0192
卷: 48, 期:20, 页:2192-2195
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: INDUCED BLOCKING FACTOR ; IMMUNE-RESPONSES ; IDENTIFICATION ; PROGESTERONE ; LYMPHOCYTE ; EXPRESSION ; MIGRATION ; NY-ESO-1
英文摘要:

Identification of hepatocellular carcinoma-associated tumor antigens is necessary and pivotal for specific immunotherapy in hepatocellular carcinoma (HCC) patients. In the present study, HCC cDNAs are constructed into ZAP cDNA expression library and screened by sera of patients with HCC. The positive clones are DNA sequenced and analyzed by bioinformatics. Thirty-one genes of hepatocellular carcinoma-associated tumor antigens are identified, of which 1 is unknown and 30 are known. The proteins encoded by these known genes can be classified into 8 categories: constitutive molecules of hepatocytes, RNA transcription and splicing-associated molecules, protein metabolism-associated molecules, energy synthesis-associated molecules, signal transduction molecules, cell adhesion molecules, immunosuppressive molecules, and proteins with unknown function. Among these genes, CAGE is a cancer-testis (CT) antigen. It is concluded that identification of hepatocellular carcinoma-associated tumor antigens provides potential targets for immunotherapy of HCC patients and facilitates explanation of carcinogenesis of HCC.

语种: 英语
WOS记录号: WOS:000186305600009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60789
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Shandong Univ, Dept Immunol, Sch Med, Jinan 250012, Peoples R China

Recommended Citation:
Shi, YY,Wang, HC,Li, Y,et al. Screening and analysis of hepatocellular carcinoma-associated antigens and their encoding genes[J]. CHINESE SCIENCE BULLETIN,2003,48(20):2192-2195.
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