|Prevalence of polycystic ovary syndrome in women in China: a large community-based study|
|Li, Rong1; Zhang, Qiufang1; Yang, Dongzi2; Li, Shangwei3; Lu, Shulan4; Wu, Xiaoke5; Wei, Zhaolian6; Song, Xueru7; Wang, Xiuxia8; Fu, Shuxin9; Lin, Jinfang10; Zhu, Yimin11; Jiang, Yong12; Feng, Huai L.1,13; Qiao, Jie1|
|关键词||polycystic ovary syndrome epidemiology community obesity|
|WOS标题词||Science & Technology|
|类目[WOS]||Obstetrics & Gynecology ; Reproductive Biology|
|研究领域[WOS]||Obstetrics & Gynecology ; Reproductive Biology|
|关键词[WOS]||METABOLIC SYNDROME ; RISK ; METAANALYSIS ; HIRSUTISM ; CONSENSUS ; CRITERIA ; DISEASE|
What is the prevalence of polycystic ovary syndrome (PCOS) in Han Chinese women from different communities?
The prevalence of PCOS in Chinese women aged 1945 years is 5.6.
The prevalence of PCOS is reported to range from 5 to 10 but to the best of our knowledge the Han Chinese population has not been studied.
A large-scale epidemiological study was carried out between October 2007 and September 2011 in 15 924 Han Chinese women of reproductive age (1945 years) from the 10 provinces and municipalities in China.
A total of 16 886 women from 152 cities and 112 villages were involved in the study. All study participants received a questionnaire and underwent a physical and transvaginal ultrasound examination. Blood samples were collected from a subsample of women (n 3565) for analysis of metabolic markers and hormones. Based on the Rotterdam PCOS criteria, we assessed hyperandrogenism (H), chronic anovulation (O) and polycystic ovaries (P). Following diagnosis, women with PCOS were assigned to one of four different phenotypes. Finally, the prevalence and related risks of PCOS among Chinese women were estimated based on all the data sources.
A total of 16 886 women were initially involved in the study and 15 924 eligible participants then completed the study; the overall response rate was 94.3 (15 924/16 886). The prevalence of PCOS in the Chinese community population was 5.6 (894/15 924). Blood samples were analyzed from 833 of these women who were assigned to the four PCOS phenotypes as follows: 19 H O, 37 H P, 15 O P and 29 H O P. Comparing the 833 women with PCOS to 2732 women without PCOS indicated that PCOS occurs in younger women (P 0.05) and these women were prone not only to menstrual problems, hyperandrogenism, PCO and infertility but also metabolic syndrome (MS) and insulin resistance (IR). However, there was no significant difference in the rate of hypertension or hyperlipemia between the two groups. Obese patients with PCOS had a higher rate of MS (16 versus 48), IR (7 versus 28), hypertension (8 versus 30) and hyperlipemia (48 versus 73) compared with non-obese patients (all P 0.05), respectively. The rates of metabolic complications in patients with PCOS increased with age.
Age and ethnic origin contribute to the differing manifestations of PCOS; therefore, sampling is one of the most important issues in epidemiological research into PCOS. Owing to the mobility of the Chinese population, the survey among resident populations caused a certain deviation in the age distribution.
The prevention and treatment of PCOS, particularly in those who are obese, are essential in Chinese women of reproductive age.
|资助机构||National Science Fund for Distinguished Young Scholars ; Capital Medical Development Scientific Research Fund ; National Key Technology RD Program|
|作者单位||1.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Reprod Med Ctr, Beijing 100191, Peoples R China|
2.Sun Yat Sen Univ, Dept Obstet & Gynecol, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
3.Sichuan Univ, Dept Obstet & Gynecol, Reprod Med Ctr, West China Univ Hosp 2, Chengdu 610064, Peoples R China
4.Xi An Jiao Tong Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Coll Med, Xian 710049, Shanxi, Peoples R China
5.Heilongjiang Chinese Med Univ, Dept Obstet & Gyneocol, Affiliated Hosp 1, Harbin, Peoples R China
6.Anhui Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Hefei, Anhui, Peoples R China
7.Tianjin Med Univ, Dept Obstet & Gynecol, Gen Hosp, Tianjin, Peoples R China
8.China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang, Peoples R China
9.Cent S Univ, Dept Obstet & Gynecol, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
10.Fudan Univ, Dept Obstet & Gynecol, Women Hosp, Shanghai 200433, Peoples R China
11.Zhejiang Univ, Dept Obstet & Gynecol, Women Hosp, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China
12.Natl Ctr Chron & Noncommunicable Dis Control & Pe, Beijing, Peoples R China
13.Cornell Univ, Dept Obstet & Gynecol, New York Hosp, Queens Affiliated Weill Med Coll, New York, NY 10021 USA
|Li, Rong,Zhang, Qiufang,Yang, Dongzi,et al. Prevalence of polycystic ovary syndrome in women in China: a large community-based study[J]. HUMAN REPRODUCTION,2013,28(9):2562-2569.|
|APA||Li, Rong.,Zhang, Qiufang.,Yang, Dongzi.,Li, Shangwei.,Lu, Shulan.,...&Qiao, Jie.(2013).Prevalence of polycystic ovary syndrome in women in China: a large community-based study.HUMAN REPRODUCTION,28(9),2562-2569.|
|MLA||Li, Rong,et al."Prevalence of polycystic ovary syndrome in women in China: a large community-based study".HUMAN REPRODUCTION 28.9(2013):2562-2569.|