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学科主题: 药学
题名:
Nine 2-(2-Phenylethyl)chromone Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibition of LPS-Induced NO Production in RAW 264.7 Cells
作者: Chen, Dong1; Xu, Zhengren1; Chai, Xingyun2; Zeng, Kewu1; Jia, Yanxing1; Bi, Dan1; Ma, Zhizhong1; Tu, Pengfei1
关键词: Biological activity ; Chromones ; Configuration determination ; Anti-inflammatory agents ; Eaglewood ; Natural products
刊名: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2012-09-01
DOI: 10.1002/ejoc.201200725
期: 27, 页:5389-5397
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: AGALWOOD JINKO ; CHINESE EAGLEWOOD ; NITRIC-OXIDE ; PHENYLETHYLCHROMONE DERIVATIVES ; BI-PHENYLETHYLCHROMONES ; CHROMONE DERIVATIVES ; AGARWOOD ; EXTRACT
英文摘要:

A phytochemical investigation of aquilariae lignum resinatum, the resinous wood of Aquilaria sinensis (Lour.) Gilg, led to the isolation of nine new 2-(2-phenylethyl)chromone derivatives, aquilarones AI (19), together with two known analogues (10 and 11). Their structures were elucidated by extensive spectroscopic analyses, including UV, IR, NMR, and electronic circular dichroism (ECD) data, as well as by chemical methods. The absolute configuration of aquilarone A (1) was confirmed by single-crystal X-ray diffraction analysis of its acetonide derivative 1a. All the compounds exhibited significant inhibition of the nitric oxide production in RAW 264.7 cells, with IC50 values in the range of 5.1222.26 mu M. In addition, an HPLCUV comparison analysis of the resinous wood and resin-free wood is also included.

语种: 英语
所属项目编号: 2009ZX311-004 ; 2009ZX0308-004 ; 30873072
项目资助者: projects of the Formulation of Pharmacopeia of China ; Ministry of Science and Technology, China ; National Natural Science Foundation of China
WOS记录号: WOS:000308580800031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60798
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

Recommended Citation:
Chen, Dong,Xu, Zhengren,Chai, Xingyun,et al. Nine 2-(2-Phenylethyl)chromone Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibition of LPS-Induced NO Production in RAW 264.7 Cells[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(27):5389-5397.
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