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Nine 2-(2-Phenylethyl)chromone Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibition of LPS-Induced NO Production in RAW 264.7 Cells
Chen, Dong1; Xu, Zhengren1; Chai, Xingyun2; Zeng, Kewu1; Jia, Yanxing1; Bi, Dan1; Ma, Zhizhong1; Tu, Pengfei1
关键词Biological activity Chromones Configuration determination Anti-inflammatory agents Eaglewood Natural products
刊名EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2012-09-01
DOI10.1002/ejoc.201200725
27页:5389-5397
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]AGALWOOD JINKO ; CHINESE EAGLEWOOD ; NITRIC-OXIDE ; PHENYLETHYLCHROMONE DERIVATIVES ; BI-PHENYLETHYLCHROMONES ; CHROMONE DERIVATIVES ; AGARWOOD ; EXTRACT
英文摘要

A phytochemical investigation of aquilariae lignum resinatum, the resinous wood of Aquilaria sinensis (Lour.) Gilg, led to the isolation of nine new 2-(2-phenylethyl)chromone derivatives, aquilarones AI (19), together with two known analogues (10 and 11). Their structures were elucidated by extensive spectroscopic analyses, including UV, IR, NMR, and electronic circular dichroism (ECD) data, as well as by chemical methods. The absolute configuration of aquilarone A (1) was confirmed by single-crystal X-ray diffraction analysis of its acetonide derivative 1a. All the compounds exhibited significant inhibition of the nitric oxide production in RAW 264.7 cells, with IC50 values in the range of 5.1222.26 mu M. In addition, an HPLCUV comparison analysis of the resinous wood and resin-free wood is also included.

语种英语
WOS记录号WOS:000308580800031
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60798
专题北京大学药学院
北京大学基础医学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
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GB/T 7714
Chen, Dong,Xu, Zhengren,Chai, Xingyun,et al. Nine 2-(2-Phenylethyl)chromone Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibition of LPS-Induced NO Production in RAW 264.7 Cells[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(27):5389-5397.
APA Chen, Dong.,Xu, Zhengren.,Chai, Xingyun.,Zeng, Kewu.,Jia, Yanxing.,...&Tu, Pengfei.(2012).Nine 2-(2-Phenylethyl)chromone Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibition of LPS-Induced NO Production in RAW 264.7 Cells.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(27),5389-5397.
MLA Chen, Dong,et al."Nine 2-(2-Phenylethyl)chromone Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibition of LPS-Induced NO Production in RAW 264.7 Cells".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .27(2012):5389-5397.
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