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学科主题: 临床医学
题名:
EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells
作者: Zhang, Yingdong1; Wang, Junjie1; Liu, Feng1; You, Zhenyu1; Yang, Ruijie1; Zhao, Yong2
刊名: CANCER CELL INTERNATIONAL
发表日期: 2010-10-23
DOI: 10.1186/1475-2867-10-39
卷: 10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; NECK-CANCER ; HEAD ; CETUXIMAB ; MUTATIONS ; RADIATION ; KINASE ; RADIOTHERAPY ; CARCINOMA ; BLOCKADE
英文摘要:

Background: The purpose of the present study is to investigate the direct biological effects of the epidermal growth factor receptor (EGFR) inhibitor C225 on the radiosensitivity of human lung squamous cancer cell-H520. H520 cells were treated with different dosage of (60)Co gamma ray irradiation (1.953 Gy/min) in the presence or absence of C225. The cellular proliferation, colony forming capacity, apoptosis, the cell cycle distribution as well as caspase-3 were analyzed in vitro.

Results: We found that C225 treatment significantly increased radiosensitivity of H-520 cells to irradiation, and led to cell cycle arrest in G(1) phase, whereas (60)Co gamma ray irradiation mainly caused G(2) phase arrest. H-520 cells thus displayed both the G(1) and G(2) phase arrest upon treatment with C225 in combination with (60)Co gamma ray irradiation. Moreover, C225 treatment significantly increased the apoptosis percentage of H-520 cells (13.91% +/- 1.88%) compared with the control group (5.75% +/- 0.64%, P < 0.05).

Conclusion: In this regard, C225 treatment may make H-520 cells more sensitive to irradiation through the enhancement of caspase-3 mediated tumor cell apoptosis and cell cycle arrest.

语种: 英语
所属项目编号: 18
项目资助者: Ministry of Civil Affair, China
WOS记录号: WOS:000284001800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60799
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Ctr Canc, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Transplantat Biol Res Div, Beijing 100101, Peoples R China

Recommended Citation:
Zhang, Yingdong,Wang, Junjie,Liu, Feng,et al. EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells[J]. CANCER CELL INTERNATIONAL,2010,10.
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