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学科主题临床医学
EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells
Zhang, Yingdong1; Wang, Junjie1; Liu, Feng1; You, Zhenyu1; Yang, Ruijie1; Zhao, Yong2
刊名CANCER CELL INTERNATIONAL
2010-10-23
DOI10.1186/1475-2867-10-39
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; NECK-CANCER ; HEAD ; CETUXIMAB ; MUTATIONS ; RADIATION ; KINASE ; RADIOTHERAPY ; CARCINOMA ; BLOCKADE
英文摘要

Background: The purpose of the present study is to investigate the direct biological effects of the epidermal growth factor receptor (EGFR) inhibitor C225 on the radiosensitivity of human lung squamous cancer cell-H520. H520 cells were treated with different dosage of (60)Co gamma ray irradiation (1.953 Gy/min) in the presence or absence of C225. The cellular proliferation, colony forming capacity, apoptosis, the cell cycle distribution as well as caspase-3 were analyzed in vitro.

Results: We found that C225 treatment significantly increased radiosensitivity of H-520 cells to irradiation, and led to cell cycle arrest in G(1) phase, whereas (60)Co gamma ray irradiation mainly caused G(2) phase arrest. H-520 cells thus displayed both the G(1) and G(2) phase arrest upon treatment with C225 in combination with (60)Co gamma ray irradiation. Moreover, C225 treatment significantly increased the apoptosis percentage of H-520 cells (13.91% +/- 1.88%) compared with the control group (5.75% +/- 0.64%, P < 0.05).

Conclusion: In this regard, C225 treatment may make H-520 cells more sensitive to irradiation through the enhancement of caspase-3 mediated tumor cell apoptosis and cell cycle arrest.

语种英语
WOS记录号WOS:000284001800001
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60799
专题北京大学第三临床医学院_肿瘤放疗科
作者单位1.Peking Univ Third Hosp, Ctr Canc, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Transplantat Biol Res Div, Beijing 100101, Peoples R China
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GB/T 7714
Zhang, Yingdong,Wang, Junjie,Liu, Feng,et al. EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells[J]. CANCER CELL INTERNATIONAL,2010,10.
APA Zhang, Yingdong,Wang, Junjie,Liu, Feng,You, Zhenyu,Yang, Ruijie,&Zhao, Yong.(2010).EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells.CANCER CELL INTERNATIONAL,10.
MLA Zhang, Yingdong,et al."EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells".CANCER CELL INTERNATIONAL 10(2010).
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