IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Repurposing of Yunnan Baiyao as an Alternative Therapy for Minor Recurrent Aphthous Stomatitis
Liu, Xiaosong1; Guan, Xiaobing2; Chen, Ruiyang3; Hua, Hong1; Liu, Yang1; Yan, Zhimin1
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2012
DOI10.1155/2012/284620
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]MANAGEMENT ; ULCERATION ; DIAGNOSIS ; DISEASE ; IL-10 ; RAU
英文摘要

The study was designed to evaluate the efficacy and safety of an herbal extract of Yunnan Baiyao formulated in toothpaste as an alternative therapy for minor RAS. A randomized, double-blind, placebo-controlled clinical trial (from March 2010 to March 2011) was conducted on a cohort of 227 minor RAS patients. The toothpaste containing Yunnan Baiyao was used twice daily as part of the patient′s routine oral hygiene for 5 days. An assessment of ulcerative size and pain was recorded on day 0 (baseline), day 3, and day 5. Any noted adverse reactions were recorded. All data were analyzed using the SAS software 8.0. As a result, the toothpaste containing Yunnan Baiyao began to present noticeable effectiveness on ulcer healing (ulcer size) by day 3 (27.5% versus 15.8%, P < 0.05), which further improved by day 5 when compared to the placebo (66.4% versus 50.0%, P = 0.01). A significant difference in alleviating pain was noted on day 5 for those who used the toothpaste containing Yunnan Baiyao (66.4% versus 51.8%, P < 0.05). No side effects were noted as a result of the Yunnan Baiyao. Therefore, Yunnan Baiyao may provide an alternative therapy for minor ulcers by promoting healing.

语种英语
WOS记录号WOS:000312314400001
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60804
专题北京大学口腔医学院
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Med, Beijing 100081, Peoples R China
2.Capital Med Univ, Beijing Stomatol Hosp, Dept Periodont & Oral Med, Beijing 100050, Peoples R China
3.Nankai Univ, Tianjin Stomatol Hosp, Dept Oral Med, Tianjin 300041, Peoples R China
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GB/T 7714
Liu, Xiaosong,Guan, Xiaobing,Chen, Ruiyang,et al. Repurposing of Yunnan Baiyao as an Alternative Therapy for Minor Recurrent Aphthous Stomatitis[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012.
APA Liu, Xiaosong,Guan, Xiaobing,Chen, Ruiyang,Hua, Hong,Liu, Yang,&Yan, Zhimin.(2012).Repurposing of Yunnan Baiyao as an Alternative Therapy for Minor Recurrent Aphthous Stomatitis.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Liu, Xiaosong,et al."Repurposing of Yunnan Baiyao as an Alternative Therapy for Minor Recurrent Aphthous Stomatitis".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012).
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