学科主题基础医学
WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts
Cao, Xiaoxiao; Xue, Lixiang; Han, Limin; Ma, Liwei; Chen, Tianda; Tong, Tanjun
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2011-09-23
DOI10.1074/jbc.M111.225565
286期:38页:33447-33456
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]KRUPPEL-LIKE FACTOR ; CAENORHABDITIS-ELEGANS ; BREAST-CANCER ; PATHWAY ; TARGET ; TRANSCRIPTION ; BINDING ; CELLS ; RB
英文摘要

WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) plays an important role in the proliferation of tumor cells and the lifespan of Caenorhabditis elegans. However, the role of WWP1 in cellular senescence is still unknown. Here, we show that the expression patterns of p27(Kip1) and WWP1 are inversely correlated during cellular senescence. Moreover, the overexpression of WWP1 delayed senescence, whereas the knockdown of WWP1 led to premature senescence in human fibroblasts. Furthermore, we demonstrate that WWP1 repressed endogenous p27(Kip1) expression through ubiquitin-proteasome-mediated degradation. Additionally, WWP1 had a strong preference for catalyzing the Lys-48-linked polyubiquitination of p27(Kip1) in vitro. Finally, we demonstrate that WWP1 markedly inhibited the replicative senescence induced by p27(Kip1) by promoting p27(Kip1) degradation. Therefore, our study provides a new molecular mechanism for the regulation of cellular senescence.

语种英语
WOS记录号WOS:000294968800062
项目编号2007CB507400 ; 30973146
资助机构Special Funds for Major State Basis Research of China ; National Natural Science Foundation of China
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60805
专题北京大学基础医学院_北京大学衰老研究中心
北京大学基础医学院
北京大学精神卫生研究所_精神科
作者单位Peking Univ, Res Ctr Aging, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Cao, Xiaoxiao,Xue, Lixiang,Han, Limin,et al. WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(38):33447-33456.
APA Cao, Xiaoxiao,Xue, Lixiang,Han, Limin,Ma, Liwei,Chen, Tianda,&Tong, Tanjun.(2011).WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts.JOURNAL OF BIOLOGICAL CHEMISTRY,286(38),33447-33456.
MLA Cao, Xiaoxiao,et al."WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts".JOURNAL OF BIOLOGICAL CHEMISTRY 286.38(2011):33447-33456.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
J. Biol. Chem.-2011-(2004KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Cao, Xiaoxiao]的文章
[Xue, Lixiang]的文章
[Han, Limin]的文章
百度学术
百度学术中相似的文章
[Cao, Xiaoxiao]的文章
[Xue, Lixiang]的文章
[Han, Limin]的文章
必应学术
必应学术中相似的文章
[Cao, Xiaoxiao]的文章
[Xue, Lixiang]的文章
[Han, Limin]的文章
相关权益政策
暂无数据
收藏/分享
文件名: J. Biol. Chem.-2011-Cao-33447-56.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。