IR@PKUHSC  > 北京大学基础医学院  > 北京大学衰老研究中心
学科主题基础医学
WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts
Cao, Xiaoxiao; Xue, Lixiang; Han, Limin; Ma, Liwei; Chen, Tianda; Tong, Tanjun
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2011-09-23
DOI10.1074/jbc.M111.225565
286期:38页:33447-33456
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
资助者Special Funds for Major State Basis Research of China ; National Natural Science Foundation of China ; Special Funds for Major State Basis Research of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]KRUPPEL-LIKE FACTOR ; CAENORHABDITIS-ELEGANS ; BREAST-CANCER ; PATHWAY ; TARGET ; TRANSCRIPTION ; BINDING ; CELLS ; RB
英文摘要

WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) plays an important role in the proliferation of tumor cells and the lifespan of Caenorhabditis elegans. However, the role of WWP1 in cellular senescence is still unknown. Here, we show that the expression patterns of p27(Kip1) and WWP1 are inversely correlated during cellular senescence. Moreover, the overexpression of WWP1 delayed senescence, whereas the knockdown of WWP1 led to premature senescence in human fibroblasts. Furthermore, we demonstrate that WWP1 repressed endogenous p27(Kip1) expression through ubiquitin-proteasome-mediated degradation. Additionally, WWP1 had a strong preference for catalyzing the Lys-48-linked polyubiquitination of p27(Kip1) in vitro. Finally, we demonstrate that WWP1 markedly inhibited the replicative senescence induced by p27(Kip1) by promoting p27(Kip1) degradation. Therefore, our study provides a new molecular mechanism for the regulation of cellular senescence.

语种英语
所属项目编号2007CB507400 ; 30973146
资助者Special Funds for Major State Basis Research of China ; National Natural Science Foundation of China ; Special Funds for Major State Basis Research of China ; National Natural Science Foundation of China
WOS记录号WOS:000294968800062
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60805
Collection北京大学基础医学院_北京大学衰老研究中心
作者单位Peking Univ, Res Ctr Aging, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Cao, Xiaoxiao,Xue, Lixiang,Han, Limin,et al. WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(38):33447-33456.
APA Cao, Xiaoxiao,Xue, Lixiang,Han, Limin,Ma, Liwei,Chen, Tianda,&Tong, Tanjun.(2011).WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts.JOURNAL OF BIOLOGICAL CHEMISTRY,286(38),33447-33456.
MLA Cao, Xiaoxiao,et al."WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27(Kip1) Degradation in Human Diploid Fibroblasts".JOURNAL OF BIOLOGICAL CHEMISTRY 286.38(2011):33447-33456.
Files in This Item: Download All
File Name/Size DocType Version Access License
J. Biol. Chem.-2011-(2004KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Cao, Xiaoxiao]'s Articles
[Xue, Lixiang]'s Articles
[Han, Limin]'s Articles
百度学术
百度学术Similar articles in
[Cao, Xiaoxiao]'s Articles
[Xue, Lixiang]'s Articles
[Han, Limin]'s Articles
必应学术
必应学术Similar articles in
[Cao, Xiaoxiao]'s Articles
[Xue, Lixiang]'s Articles
[Han, Limin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: J. Biol. Chem.-2011-Cao-33447-56.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.