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学科主题: 临床医学
题名:
Effect of Modified Formula Radix Hedysari on the Amplification Effect during Peripheral Nerve Regeneration
作者: Wang, Zhi Yong; Zhang, Pei Xun; Han, Na; Kou, Yu Hui; Yin, Xiao Feng; Jiang, Bao Guo
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2013
DOI: 10.1155/2013/647982
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: GROWTH-FACTOR DELIVERY ; SPINAL-CORD ; AXON GROWTH ; INJURY
英文摘要:

Many studies have demonstrated a compensatory amplification phenomenon during nerve regeneration. When a relatively fine nerve is used as a donor to connect to a distal nerve after transection, the donor nerve regenerates more collaterals than its own fibers, which extend to the distal stump, grow into distal endoneurial tubes, and finally reach and dominate the target organs. This is known as the amplification phenomenon. In this study, we investigated the amplification phenomenon in rats treated with Modified Formula Radix Hedysari (MFRH) as adjuvant therapy for 12 weeks. The rats were divided into three groups at random (six animals in each group). In the model group and the treatment group, the proximal common peroneal nerve was used as a donor nerve to connect to the distal tibial nerve. Rats in the normal group did not undergo surgery. After surgery, the treatment group was administered MFRH as systemic therapy, while the model group and the normal group were not given treatment. The results demonstrated that the nerve conduction velocity, the fiber diameter, the axon diameter, the number of regenerating nerve fibers, and the amplification ratio were better in the treatment group than in the model group, suggesting that MFRH promoted the nerve amplification effect.

语种: 英语
所属项目编号: 31171150 ; 31271284 ; 81171146 ; 30971526 ; 30801169 ; A-2008-10 ; BMU 20110270 ; IRT1201
项目资助者: National Natural Science Fund ; Beijing City Science and Technology New Star Classification ; Educational Ministry New Century Excellent Talents Support Project ; Ministry of education innovation team
WOS记录号: WOS:000315908600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60809
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthopead, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Zhi Yong,Zhang, Pei Xun,Han, Na,et al. Effect of Modified Formula Radix Hedysari on the Amplification Effect during Peripheral Nerve Regeneration[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
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