北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Brain-Derived Neurotrophic Factor Levels and Its Val66Met Gene Polymorphism Predict Tardive Dyskinesia Treatment Response to Ginkgo Biloba
作者: Zhang, Xiang Yang1,2; Zhang, Wu-Fang3; Zhou, Dong-Feng3; Chen, Da Chun2; Xiu, Mei Hong2; Wu, Hao-Ran4; Haile, Colin N.1; Kosten, Therese A.1; Kosten, Thomas R.1,2
关键词: Brain-derived neurotrophic factor ; extract of ginkgo biloba ; genotype ; pharmacogenetics ; schizophrenia ; tardive dyskinesia
刊名: BIOLOGICAL PSYCHIATRY
发表日期: 2012-10-15
DOI: 10.1016/j.biopsych.2012.04.032
卷: 72, 期:8, 页:700-706
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: ACTIVITY-DEPENDENT SECRETION ; PLACEBO-CONTROLLED TRIAL ; DOUBLE-BLIND ; SCHIZOPHRENIC-PATIENTS ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; EXTRACT ; NEURONS ; BDNF ; ASSOCIATION
英文摘要:

Background: Tardive dyskinesia (TD) has no well-accepted treatments or known pathophysiology, but low brain-derived neurotrophic factor (BDNF) may play an important role in its pathophysiology. Ginkgo biloba (EGb-761) is a potent antioxidant that has neuroprotective effects mediated through enhancing BDNF levels. We hypothesized that treatment with EGb-761 would increase serum BDNF levels and reduce TD, particularly among schizophrenia patients who have the BDNF valine 66 to methionine (Val66Met) genotype (Val/Val).

Methods: Serum BDNF levels and genotyping for the BDNF gene Val66Met polymorphism were assessed in Chinese schizophrenic patients with (n = 368) and without (n = 563) TD as well as healthy control subjects (n = 546). About half of the TD patients (n = 157) then participated in a double-blind, randomized, placebo-control 12-week treatment with 240 mg per day of EGb-761. Serum BDNF levels were measured again at posttreatment. Clinical efficacy was determined using the Abnormal Involuntary Movement Scale (AIMS).

Results: TD patients had lower BDNF levels than the non-TD patients and healthy controls. EGb-761 treatment improved symptoms of TD and increased BDNF levels compared with placebo treatment. Moreover, the improvement of AIMS total score correlated with the increase in BDNF levels. Furthermore, improvement in the AIMS score was greatest in those with the Val/Val allele and lowest with the Met/Met allele.

Conclusions: The BDNF system may be implicated in the pathophysiology of TD and its improvement with antioxidant treatment. Furthermore, patients with the genetic potential for greater BDNF release (Val/Val at 66) may obtain a greater reduction in TD from EGb-761 treatment.

语种: 英语
所属项目编号: 03T-459 ; 05T-726 ; P50-DA18827 ; U01-MH79639
项目资助者: Stanley Medical Research Institute ; Department of Veterans Affairs, South Central VA Health Care Network (VISN 16) ; Mental Illness Research, Education and Clinical Center (MIRECC) ; U.S. National Institutes of Health
WOS记录号: WOS:000309545400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60811
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China
2.Hebei Prov Rong Jun Hosp, Baoding, Peoples R China
3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Xiang Yang,Zhang, Wu-Fang,Zhou, Dong-Feng,et al. Brain-Derived Neurotrophic Factor Levels and Its Val66Met Gene Polymorphism Predict Tardive Dyskinesia Treatment Response to Ginkgo Biloba[J]. BIOLOGICAL PSYCHIATRY,2012,72(8):700-706.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Xiang Yang]'s Articles
[Zhang, Wu-Fang]'s Articles
[Zhou, Dong-Feng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Xiang Yang]‘s Articles
[Zhang, Wu-Fang]‘s Articles
[Zhou, Dong-Feng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace