IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Brain-Derived Neurotrophic Factor Levels and Its Val66Met Gene Polymorphism Predict Tardive Dyskinesia Treatment Response to Ginkgo Biloba
Zhang, Xiang Yang1,2; Zhang, Wu-Fang3; Zhou, Dong-Feng3; Chen, Da Chun2; Xiu, Mei Hong2; Wu, Hao-Ran4; Haile, Colin N.1; Kosten, Therese A.1; Kosten, Thomas R.1,2
关键词Brain-derived neurotrophic factor extract of ginkgo biloba genotype pharmacogenetics schizophrenia tardive dyskinesia
刊名BIOLOGICAL PSYCHIATRY
2012-10-15
DOI10.1016/j.biopsych.2012.04.032
72期:8页:700-706
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Psychiatry
资助者Stanley Medical Research Institute ; Department of Veterans Affairs, South Central VA Health Care Network (VISN 16) ; Mental Illness Research, Education and Clinical Center (MIRECC) ; U.S. National Institutes of Health ; Stanley Medical Research Institute ; Department of Veterans Affairs, South Central VA Health Care Network (VISN 16) ; Mental Illness Research, Education and Clinical Center (MIRECC) ; U.S. National Institutes of Health
研究领域[WOS]Neurosciences & Neurology ; Psychiatry
关键词[WOS]ACTIVITY-DEPENDENT SECRETION ; PLACEBO-CONTROLLED TRIAL ; DOUBLE-BLIND ; SCHIZOPHRENIC-PATIENTS ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; EXTRACT ; NEURONS ; BDNF ; ASSOCIATION
英文摘要

Background: Tardive dyskinesia (TD) has no well-accepted treatments or known pathophysiology, but low brain-derived neurotrophic factor (BDNF) may play an important role in its pathophysiology. Ginkgo biloba (EGb-761) is a potent antioxidant that has neuroprotective effects mediated through enhancing BDNF levels. We hypothesized that treatment with EGb-761 would increase serum BDNF levels and reduce TD, particularly among schizophrenia patients who have the BDNF valine 66 to methionine (Val66Met) genotype (Val/Val).

Methods: Serum BDNF levels and genotyping for the BDNF gene Val66Met polymorphism were assessed in Chinese schizophrenic patients with (n = 368) and without (n = 563) TD as well as healthy control subjects (n = 546). About half of the TD patients (n = 157) then participated in a double-blind, randomized, placebo-control 12-week treatment with 240 mg per day of EGb-761. Serum BDNF levels were measured again at posttreatment. Clinical efficacy was determined using the Abnormal Involuntary Movement Scale (AIMS).

Results: TD patients had lower BDNF levels than the non-TD patients and healthy controls. EGb-761 treatment improved symptoms of TD and increased BDNF levels compared with placebo treatment. Moreover, the improvement of AIMS total score correlated with the increase in BDNF levels. Furthermore, improvement in the AIMS score was greatest in those with the Val/Val allele and lowest with the Met/Met allele.

Conclusions: The BDNF system may be implicated in the pathophysiology of TD and its improvement with antioxidant treatment. Furthermore, patients with the genetic potential for greater BDNF release (Val/Val at 66) may obtain a greater reduction in TD from EGb-761 treatment.

语种英语
所属项目编号03T-459 ; 05T-726 ; P50-DA18827 ; U01-MH79639
资助者Stanley Medical Research Institute ; Department of Veterans Affairs, South Central VA Health Care Network (VISN 16) ; Mental Illness Research, Education and Clinical Center (MIRECC) ; U.S. National Institutes of Health ; Stanley Medical Research Institute ; Department of Veterans Affairs, South Central VA Health Care Network (VISN 16) ; Mental Illness Research, Education and Clinical Center (MIRECC) ; U.S. National Institutes of Health
WOS记录号WOS:000309545400014
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60811
专题北京大学精神卫生研究所
作者单位1.Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China
2.Hebei Prov Rong Jun Hosp, Baoding, Peoples R China
3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiang Yang,Zhang, Wu-Fang,Zhou, Dong-Feng,et al. Brain-Derived Neurotrophic Factor Levels and Its Val66Met Gene Polymorphism Predict Tardive Dyskinesia Treatment Response to Ginkgo Biloba[J]. BIOLOGICAL PSYCHIATRY,2012,72(8):700-706.
APA Zhang, Xiang Yang.,Zhang, Wu-Fang.,Zhou, Dong-Feng.,Chen, Da Chun.,Xiu, Mei Hong.,...&Kosten, Thomas R..(2012).Brain-Derived Neurotrophic Factor Levels and Its Val66Met Gene Polymorphism Predict Tardive Dyskinesia Treatment Response to Ginkgo Biloba.BIOLOGICAL PSYCHIATRY,72(8),700-706.
MLA Zhang, Xiang Yang,et al."Brain-Derived Neurotrophic Factor Levels and Its Val66Met Gene Polymorphism Predict Tardive Dyskinesia Treatment Response to Ginkgo Biloba".BIOLOGICAL PSYCHIATRY 72.8(2012):700-706.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Xiang Yang]的文章
[Zhang, Wu-Fang]的文章
[Zhou, Dong-Feng]的文章
百度学术
百度学术中相似的文章
[Zhang, Xiang Yang]的文章
[Zhang, Wu-Fang]的文章
[Zhou, Dong-Feng]的文章
必应学术
必应学术中相似的文章
[Zhang, Xiang Yang]的文章
[Zhang, Wu-Fang]的文章
[Zhou, Dong-Feng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。