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学科主题临床医学
Mode and site of acupuncture modulation in the human brain: 3D (124-ch) EEG power spectrum mapping and source imaging
Chen, ACN; Liu, FJ; Wang, L; Arendt-Nielsen, L
关键词acupuncture theta EEG 3D topographic field potential mapping current source imaging cortical plasticity frequency modulation
刊名NEUROIMAGE
2006-02-15
DOI10.1016/j.neuroimage.2005.08.066
29期:4页:1080-1091
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]ANTERIOR CINGULATE CORTEX ; MIDLINE THETA RHYTHM ; NERVE-STIMULATION ; SPINAL-CORD ; INDIVIDUAL-DIFFERENCES ; ACUPOINT STIMULATION ; SENSORY STIMULATION ; SOURCE LOCALIZATION ; MANUAL ACUPUNCTURE ; PREFRONTAL CORTEX
英文摘要

This study determined: (a) if acupuncture stimulation at a traditional site might modulate ongoing EEG as compared with stimulation of a control site; (b) if high-frequency vs. low-frequency stimulation could exert differential effects of acupuncture; (c) if the observed effects of acupuncture were specific to certain EEG bands; and (d) if the acupuncture effect could be isolated at a specific scalp field, with its putative underlying intracranial source. Twelve healthy male volunteers (age range 22-35) participated in two experimental sessions separated by 1 week, which involved transcutaneous acupoint stimulation at selected acupoint (Li 4, HeGu) vs. a mock point at the fourth interosseous muscle area on the left hand in high (HF: 100 Hz) vs. low-frequency (LF: 2 Hz) stimulation by counter-balanced order. 124-ch EEG data were used to analyze the Delta, Theta, Alpha-1, Alpha-2, Beta, and Gamma bands. The absolute EEG powers (mu v(2)) at focal maxima across three stages (baseline, stimulation, post) were examined by two-way (condition, stage) repeated measures ANOVA. The activity of the Theta power significantly decreased (P = 0.02), compared with control during HF but not LF stimulation at acupoint stimulation, however, there was no study effect at the mock point. A decreased Theta EEG power was prominent at the frontal midline sites (FCz, Fz) and the contralateral right hemisphere front site (FCC2h). In contrast, the Theta power of low-frequency stimulation showed an increase from the baseline as those in both controlled mock point stimulations. The observed high-frequency acupoint stimulation effects of Theta EEG were only present during, but not after, simulation. The topographic Theta activity was tentatively identified to originate from the intracranial current source in cingulate cortex, likely ACC. It is likely that short-term cortical plasticity occurs during high-frequency but not low-frequency stimulation at the HeGu point, but not mock point. We suggest that HeGu acupuncture stimulation modulates limbic cingulum by a frequency modulation mode, which then may damp nociceptive processing in the brain. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000235534400006
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60812
专题北京大学第一临床医学院_神经内科
作者单位1.Univ Aalborg, Dept Hlth Sci & Technol, Human Brain Mapping & Cort Imaging Lab, DK-9220 Aalborg, Denmark
2.Capital Univ Med Sci, Ctr Funct Human Brain Mapping, Beijing, Peoples R China
3.Peking Univ, Sch Med, Affiliated Hosp 1, Dept Neurol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, ACN,Liu, FJ,Wang, L,et al. Mode and site of acupuncture modulation in the human brain: 3D (124-ch) EEG power spectrum mapping and source imaging[J]. NEUROIMAGE,2006,29(4):1080-1091.
APA Chen, ACN,Liu, FJ,Wang, L,&Arendt-Nielsen, L.(2006).Mode and site of acupuncture modulation in the human brain: 3D (124-ch) EEG power spectrum mapping and source imaging.NEUROIMAGE,29(4),1080-1091.
MLA Chen, ACN,et al."Mode and site of acupuncture modulation in the human brain: 3D (124-ch) EEG power spectrum mapping and source imaging".NEUROIMAGE 29.4(2006):1080-1091.
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