IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Biphasic effects of orchidectomy on calcitonin gene-related peptide synthesis and release
Sun, C; Chen, MZ; Mao, JM; Wang, X
关键词aging calcitonin gene-related peptide testosterone sensory nerve
刊名NEUROREPORT
2001-11-16
12期:16页:3497-3502
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]RAT PREOPTIC AREA ; SPINAL-CORD ; IMMUNOREACTIVITY ; ESTROGEN ; NERVES ; CGRP ; MOTONEURONS ; EXPRESSION ; RECEPTOR ; NUCLEUS
英文摘要

We hypothesize that the decline of male gonadal hormones may play a role in age-related decrease of calcitonin gene-related peptide (CGRP) synthesis and release. Orchidectomized rats were raised with or without testosterone replacement and CGRP levels in serum and some tissues as well as the perfusate from the isolated mesenteric arterial bed (MAB) were measured at 1, 2 and 4 months after orchidectomy. CGRP levels of serum and tissues, and CGRP release from MAB were significantly elevated after I month and decreased after 4 months in orchidectomized rats. The changes were restored by testosterone replacement. Our results indicate that the age-related decline of testosterone might contribute to the age-related decrease of CGRP synthesis and release. (C) 2001 Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000172175000024
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60814
专题北京大学第三临床医学院_心血管内科
作者单位Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
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GB/T 7714
Sun, C,Chen, MZ,Mao, JM,et al. Biphasic effects of orchidectomy on calcitonin gene-related peptide synthesis and release[J]. NEUROREPORT,2001,12(16):3497-3502.
APA Sun, C,Chen, MZ,Mao, JM,&Wang, X.(2001).Biphasic effects of orchidectomy on calcitonin gene-related peptide synthesis and release.NEUROREPORT,12(16),3497-3502.
MLA Sun, C,et al."Biphasic effects of orchidectomy on calcitonin gene-related peptide synthesis and release".NEUROREPORT 12.16(2001):3497-3502.
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