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学科主题: 临床医学
题名:
Biphasic effects of orchidectomy on calcitonin gene-related peptide synthesis and release
作者: Sun, C; Chen, MZ; Mao, JM; Wang, X
关键词: aging ; calcitonin gene-related peptide ; testosterone ; sensory nerve
刊名: NEUROREPORT
发表日期: 2001-11-16
卷: 12, 期:16, 页:3497-3502
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: RAT PREOPTIC AREA ; SPINAL-CORD ; IMMUNOREACTIVITY ; ESTROGEN ; NERVES ; CGRP ; MOTONEURONS ; EXPRESSION ; RECEPTOR ; NUCLEUS
英文摘要:

We hypothesize that the decline of male gonadal hormones may play a role in age-related decrease of calcitonin gene-related peptide (CGRP) synthesis and release. Orchidectomized rats were raised with or without testosterone replacement and CGRP levels in serum and some tissues as well as the perfusate from the isolated mesenteric arterial bed (MAB) were measured at 1, 2 and 4 months after orchidectomy. CGRP levels of serum and tissues, and CGRP release from MAB were significantly elevated after I month and decreased after 4 months in orchidectomized rats. The changes were restored by testosterone replacement. Our results indicate that the age-related decline of testosterone might contribute to the age-related decrease of CGRP synthesis and release. (C) 2001 Lippincott Williams & Wilkins.

语种: 英语
WOS记录号: WOS:000172175000024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60814
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China

Recommended Citation:
Sun, C,Chen, MZ,Mao, JM,et al. Biphasic effects of orchidectomy on calcitonin gene-related peptide synthesis and release[J]. NEUROREPORT,2001,12(16):3497-3502.
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