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学科主题: 临床医学
题名:
Midline NK/T-cell lymphoma nasal-type: treatment outcome, the effect of L-asparaginase based regimen, and prognostic factors
作者: Yong, WB; Zheng, W; Zhu, J; Zhang, YT; Wei, Y; Wang, XP; Lin, NJ; Xie, Y; Xu, B; Li, JY
关键词: midline NK/T-cell lymphoma ; treatment ; L-asparaginase ; prognosis
刊名: HEMATOLOGICAL ONCOLOGY
发表日期: 2006-03-01
DOI: 10.1002/hon.765
卷: 24, 期:1, 页:28-32
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: NATURAL KILLER/T-CELL ; T-CELL ; CLASSIFICATION ; CHEMOTHERAPY ; EXPRESSION ; NEOPLASMS ; RADIATION
英文摘要:

Purpose: Midline NK/T-cell lymphoma nasal-type is an aggressive neoplasm with poor prognosis in most instances. To improve the treatment outcome, we have tried using L-asparaginase based regimen as salvage regimen plus radiation in CHOP failures, and report here the therapeutic results and prognostic factors. Patients and methods: From March 1992 to January 2005, 46 Chinese patients with midline NK/T-cell lymphoma nasal-type were initially treated with CHOP regimen as first-line chemotherapy. The patients who failed CHOP regimens were altered to receive L-asparaginase based salvage regimen. All the patients received primary involved-field radiation after chemotherapy. Results: Thirteen patients (28.3%) sensitive to CHOP regimen received CHOP regimen for 6 cycles plus locoregional radiation, and achieved complete remission (CR). Thirty-three patients failed CHOP regimen were altered to received L-asparaginase-based salvage regimen for 2 similar to 6 cycles (median 3 cycles) plus locoregional radiation, and seventeen of the 33 CHOP failures (51.5%) (L-asparaginase group) reached CR. The CR rate for the whole group was 65.2% (30/46 cases). The 5-year overall survival (OS) rates were 64.5% for the whole group and 55.9% for L-asparaginase group, respectively. On univariate analysis, disease stage, fever symptom and performance status were significant factors influencing overall survival. On multivariate analysis, only disease stage and fever symptom remained as independently significant factors influencing OS. Conclusion: In this preliminary study, the results indicated that L-asparaginase based regimen might be a promising new salvage chemotherapeutic regimen in CHOP failures and conduce to improve the treatment outcome in midline NK/T-cell lymphoma, nasal-type. Copyright (c) 2005 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000236408700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60818
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: Peking Univ, Beijing Canc Hosp, Sch Oncol, Dept Med Oncol, Beijing 100036, Peoples R China

Recommended Citation:
Yong, WB,Zheng, W,Zhu, J,et al. Midline NK/T-cell lymphoma nasal-type: treatment outcome, the effect of L-asparaginase based regimen, and prognostic factors[J]. HEMATOLOGICAL ONCOLOGY,2006,24(1):28-32.
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