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学科主题: 药学
题名:
Sialylation reactions with N,N-dibenzylthiosialoside donor
作者: Wang, Yue; Xu, Fei-Fei; Ye, Xin-Shan1
关键词: Sialylation ; Stereoselectivity ; Carbohydrate ; Synthetic method
刊名: TETRAHEDRON LETTERS
发表日期: 2012-07-11
DOI: 10.1016/j.tetlet.2012.05.024
卷: 53, 期:28, 页:3658-3662
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ALPHA-SELECTIVE SIALYLATIONS ; N-ACETYLNEURAMINIC ACID ; ACETYL-NEURAMINIC ACID ; CELL-SURFACE GLYCANS ; ONE-POT SYNTHESIS ; SIALIC-ACID ; STEREOSELECTIVE-SYNTHESIS ; GLYCOSYL DONOR ; O-SIALYLATION ; DERIVATIVES
英文摘要:

A new sialyl donor, N,N-dibenzyl-protected p-toluenethiosialoside, was synthesized and its sialylation reaction was investigated. This reaction proceeded in a preactivation manner and preferred to provide beta-anomeric coupling products. The beta-selectivity was rationalized based on the assumption that N,N-dibenzylamino group could serve as an oriented group to activate the hydroxyl group of acceptor from beta-face. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2012AA021504 ; 2012CB822100
项目资助者: National High Technology Research and Development Program of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000305856100029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60820
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Yue,Xu, Fei-Fei,Ye, Xin-Shan. Sialylation reactions with N,N-dibenzylthiosialoside donor[J]. TETRAHEDRON LETTERS,2012,53(28):3658-3662.
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