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学科主题: 临床医学
题名:
HER2 Status in Gastric and Gastroesophageal Junction Cancer Assessed by Local and Central Laboratories: Chinese Results of the HER-EAGLE Study
作者: Huang, Dan1,2; Lu, Ning3; Fan, Qinhe4; Sheng, Weiqi1,2; Bu, Hong5; Jin, Xiaolong6; Li, Guimei7; Liu, Yanhui8; Li, Xianghong9; Sun, Wenyong10; Zhang, Huizhong11; Li, Xiaobing12; Zhou, Zongguang13; Yan, Min14,15; Wang, Xuan16; Sha, Weihong17; Ji, Jiafu18; Cheng, Xiangdong19; Zhou, Zhiwei20; Xu, Jianming21; Du, Xiang1,2
刊名: PLOS ONE
发表日期: 2013-11-14
DOI: 10.1371/journal.pone.0080290
卷: 8, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: IN-SITU HYBRIDIZATION ; SCORING SYSTEM ; EXPRESSION ; MORTALITY ; VALIDATION ; ESOPHAGEAL ; CARCINOMA ; BREAST ; CARDIA
英文摘要:

Trastuzumab has been approved for human epidermal growth factor receptor 2 (HER2)-positive advanced gastric and gastroesophageal junction cancers (GC and GJC) in combination with chemotherapy. The aim of this HER2 early/advanced gastric epidemiology (HER-EAGLE) study was to evaluate the frequency of HER2 over-expression and to evaluate agreement on HER2 status assessment in GC and GJC patients in local laboratories versus a central laboratory in China. Tumor samples from 734 GC or GJC patients who were enrolled at 11 different hospitals in China were examined. HER2 status was assessed by immunohistochemistry (IHC), and followed by dual-color silver-enhanced in Situ hybridization (DSISH) in IHC 2+ cases. Clinicopathologic characteristics were collected from all of the patients. HER2-positive tumors were identified in 12.0% (88/734) of the GC and GJC cases. There were significantly higher rates of HER2 positivity in patients with GJC (GJC: 18.1%, GC: 9.7%, P=0.002), and intestinal-type cancers using the Lauren classification (intestinal: 23.6%, diffuse/mixed: 4.3%, P<0.0001). No significant difference in HER2 positivity was identified between resection and biopsy samples, or between early and advanced disease stages. The agreement between local laboratories and the central laboratory on HER2 status scoring was good (kappa=0.86). The main reason of HER2 status discordance between local and the central laboratories was IHC result mis-interpretation in local laboratories. These results suggest that IHC followed by DSISH testing is an accurate and cost-effective procedure in China.

语种: 英语
项目资助者: Shanghai ROCHE pharmaceuticals Ltd.
WOS记录号: WOS:000327143800140
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60827
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Jiangsu Prov Hosp, Dept Pathol, Nanjing, Jiangsu, Peoples R China
2.PLA Hosp, Dept Pathol, Nanjing, Jiangsu, Peoples R China
3.Beijing Canc Hosp, Dept Pathol, Beijing, Peoples R China
4.Zhejiang Canc Hosp, Dept Pathol, Hangzhou, Zhejiang, Peoples R China
5.PLA 307 Hosp, Dept Pathol, Beijing, Peoples R China
6.PLA Hosp, Dept Surg, Nanjing, Jiangsu, Peoples R China
7.PLA 307 Hosp, Dept Gastrointestinal Oncol, Beijing, Peoples R China
8.Fudan Univ, Ctr Canc, Dept Pathol, Shanghai 200433, Peoples R China
9.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China
10.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Pathol, Beijing 100730, Peoples R China
11.Sichuan Univ, West China Hosp, Dept Pathol, Chengdu 610064, Peoples R China
12.Shanghai Jiao Tong Univ, Sch Med, Ruijing Hosp, Dept Pathol, Shanghai 200030, Peoples R China
13.Guangdong Gen Hosp, Dept Pathol, Guangzhou, Guangdong, Peoples R China
14.Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510275, Guangdong, Peoples R China
15.Sichuan Univ, West China Hosp, Ctr Gastrointestinal Surg, Chengdu 610064, Peoples R China
16.Shanghai Jiao Tong Univ, Sch Med, Ruijing Hosp, Dept Surg, Shanghai 200030, Peoples R China
17.Shanghai Jiao Tong Univ, Sch Med, Ruijing Hosp, Shanghai Inst Digest Surg, Shanghai 200030, Peoples R China
18.Guangdong Gen Hosp, Dept Gastroenterol, Guangzhou, Guangdong, Peoples R China
19.Beijing Canc Hosp, Dept Gastrointestinal Surg, Beijing, Peoples R China
20.Zhejiang Canc Hosp, Dept Abdominal Surg, Hangzhou, Zhejiang, Peoples R China
21.Sun Yat Sen Univ, Ctr Canc, Dept Gastr & Pancreat Surg, Guangzhou 510275, Guangdong, Peoples R China

Recommended Citation:
Huang, Dan,Lu, Ning,Fan, Qinhe,et al. HER2 Status in Gastric and Gastroesophageal Junction Cancer Assessed by Local and Central Laboratories: Chinese Results of the HER-EAGLE Study[J]. PLOS ONE,2013,8(11).
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