IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Assay of ischemia-modified albumin and C-reactive protein for early diagnosis of acute coronary syndromes
Cui Liyan; Zhang Jie; Wu Yonghua; Hu Xiaozhou
关键词C reactive protein (CRP) myocardial ischemia ROC curve
刊名JOURNAL OF CLINICAL LABORATORY ANALYSIS
2008
DOI10.1002/jcla.20223
22期:1页:45-49
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; LONG-TERM MORTALITY ; ARTERY-DISEASE ; EMERGENCY-DEPARTMENT ; TISSUE-INJURY ; ADMISSION ; THROMBOLYSIS ; INFLAMMATION ; DAMAGE ; RISK
英文摘要

Diagnosis of cardiac ischemia in patients coming to emergency departments (ED) with symptoms of acute chest pain is often difficult. Many markers are sensitive and specific for the detection of myocardial necrosis but may not rise during reversible myocardial ischemia. Ischemia-modified albumin (IMA) has recently been shown to be a sensitive and early biochemical marker of ischemia. The variation laws were observed by measuring IMA and C-reactive protein (CRP) of 113 patients in ED within 12 hr after onset of chest pain. In the observation, blood was taken for IMA and CRP. Patients underwent standardized triage, diagnostic procedures, and treatment. Results of IMA and CRP were correlated with final diagnoses of nonischemic chest pain (NICP) and acute coronary syndrome (ACS). There were obvious distinction of IMA and CRP levels between the NICP and ACS groups. Receiver operator characteristic (ROC) curve analysis was used to determine the optimal cutoff of this assay for identifying individuals with ACS patients from NICP. The area under the curves of IMA is 0.948. The sensitivity and specificity of albumin cobalt binding (ACB) at a cutoff value of 70.Ounits/mL were 94.4% and 82.6%, respectively. The area under the curves of CRP is 0.746. Sensitivity and specificity of CRP at a cutoff value of 3.16 mg/L were 70.0% and 73.9%, respectively. Negative predictive value (NPV) of IMA and CRP for ischemia origin was 79.2% and 38.6%, respectively. IMA may make an early diagnosis of acute coronary ischemia, and will improve the early diagnostic sensitivity and specificity of ACS.

语种英语
WOS记录号WOS:000253587800007
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60830
专题北京大学第三临床医学院
北京大学第三临床医学院_检验科
作者单位Peking Univ, Hosp 3, Dept Lab Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Cui Liyan,Zhang Jie,Wu Yonghua,et al. Assay of ischemia-modified albumin and C-reactive protein for early diagnosis of acute coronary syndromes[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2008,22(1):45-49.
APA Cui Liyan,Zhang Jie,Wu Yonghua,&Hu Xiaozhou.(2008).Assay of ischemia-modified albumin and C-reactive protein for early diagnosis of acute coronary syndromes.JOURNAL OF CLINICAL LABORATORY ANALYSIS,22(1),45-49.
MLA Cui Liyan,et al."Assay of ischemia-modified albumin and C-reactive protein for early diagnosis of acute coronary syndromes".JOURNAL OF CLINICAL LABORATORY ANALYSIS 22.1(2008):45-49.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Cui Liyan]的文章
[Zhang Jie]的文章
[Wu Yonghua]的文章
百度学术
百度学术中相似的文章
[Cui Liyan]的文章
[Zhang Jie]的文章
[Wu Yonghua]的文章
必应学术
必应学术中相似的文章
[Cui Liyan]的文章
[Zhang Jie]的文章
[Wu Yonghua]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。