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学科主题: 基础医学
题名:
Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the Fe gamma RI and TLR4 pathways
作者: Zhang, Jie1; Niu, Na2; Wang, Mingyu3; McNutt, Michael A.4; Zhang, Donghong5,6; Zhang, Baogang1; Lu, Shijun1; Liu, Yuqing1; Liu, Zhihui3
关键词: Neuron-derived IgG ; Parkinson&prime ; s disease ; Microglia ; Fc gamma R I ; TLR4
刊名: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
发表日期: 2013-08-01
DOI: 10.1016/j.bioce1.2013.06.005
卷: 45, 期:8, 页:1911-1920
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; CENTRAL-NERVOUS-SYSTEM ; PARKINSONS-DISEASE ; FC-RECEPTORS ; MURINE MICROGLIA ; CELL-DEATH ; BRAIN ; INFLAMMATION ; EXPRESSION ; NEURODEGENERATION
英文摘要:

Oxidative and immune attacks from the environment or microglia have been implicated in the loss of dopaminergic neurons of Parkinson′s disease. The role of IgG which is an important immunologic molecule in the process of Parkinson′s disease has been unclear. Evidence suggests that IgG can be produced by neurons in addition to its traditionally recognized source B lymphocytes, but its function in neurons is poorly understood. In this study, extensive expression of neuron-derived IgG was demonstrated in dopaminergic neurons of human and rat mesencephalon. With an in vitro Parkinson′s disease model, we found that neuron-derived IgG can improve the survival and reduce apoptosis of dopaminergic neurons induced by 6-hydroxydopamine toxicity, and also depress the release of NO from microglia triggered by 6-hydroxydopamine. Expression of TNF-alpha and IL-10 in microglia was elevated to protective levels by neuron-derived IgG at a physiologic level via the Fc gamma R I and TLR4 pathways and microglial activation could be attenuated by IgG blocking. All these data suggested that neuron-derived IgG may exert a self-protective function by activating microglia properly, and IgG may be involved in maintaining immunity homeostasis in the central nervous system and serve as an active factor under pathological conditions such as Parkinson′s disease. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81100885 ; BS2011SW051
项目资助者: National Natural Science Foundation of China ; Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province
WOS记录号: WOS:000322925200042
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60834
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Weifang Med Univ, Dept Human Anat, Weifang 261053, Peoples R China
2.Weifang Med Univ, Dept Pathol, Weifang 261053, Peoples R China
3.Weifang Med Univ, Affiliated Hosp, Dept Neurol, Weifang 261031, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
5.Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing 100730, Peoples R China
6.Peking Union Med Coll, Beijing 100730, Peoples R China

Recommended Citation:
Zhang, Jie,Niu, Na,Wang, Mingyu,et al. Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the Fe gamma RI and TLR4 pathways[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2013,45(8):1911-1920.
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