IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Potential Interactions Between Genetic Polymorphisms of the Transforming Growth Factor-beta Pathway and Environmental Factors in Abdominal Aortic Aneurysms
Zuo, S.1; Xiong, J.1; Wei, Y.2; Chen, D.2; Chen, F.1; Liu, K.2; Wu, T.2; Hu, Y.2; Guo, W.1
关键词Abdominal Aortic Aneurysm Gene-environment Interaction Gmdr
刊名EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
2015-07-01
DOI10.1016/j.ejvs.2015.04.010
50期:1页:71-77
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Peripheral Vascular Disease
研究领域[WOS]Surgery ; Cardiovascular System & Cardiology
关键词[WOS]Genome-wide Association ; Sequence Variant ; Susceptibility ; Disease ; Atherosclerosis ; Metaanalysis ; Population ; Agtr1 ; Tgfb1 ; Ace
英文摘要

Objective/Background: Evidence has accumulated that multiple polymorphisnns in the transforming growth factor (TGF)-beta pathway and renin angiotensin system play important roles in determining susceptibility to abdominal aortic aneurysm (AAA). Few studies have considered interactions between these gene polymorphisms and environmental factors. The aim of this study was to evaluate the contribution of single nucleotide polymorphisnns (SNPs) and complex gene environment interactions in AAA.

Methods: Six SNPs located in TGFB, TGFBR1, TGFBR2 and AGTR1 were selected. Genotyping of blood samples and collection of lifestyle factors were performed in 155 unrelated participants with AAAs and 310 non-AAA controls. Unconditional logistic regression was performed to assess the effects of SNPs on the risk of AAA. Generalized multifactor dimensionality reduction (GMDR) was used to evaluate gene gene and gene environment interactions.

Results: Participants carrying TGFB1 rs1800469 IT (odds ratio [OR] 1.83, 95% confidence interval [Cl] 1.18-2.85) or AGTR1 rs12695895 TT (OR 4.21, 95% Cl 1.41-12.53) genotypes had a higher risk of AAA than those with the common CC genotype. The gene gene interaction of AGTR1 rs5182, TGFBR1 rs1626340, and TGFB1 rs1800469 was found to be the best model according to the results of the GMDR analysis (cross validation consistency [CVC]) 10/10; p = .010). Smoking, dyslipidemia, and rs1800469 together contributed to the risk of AAA, which demonstrated a potential and complex gene environment interaction among the three variants that might affect AAA risk (CVC 6/10; p = .001).

Conclusion: In this study of the Chinese population, homozygosity of TGFB1 rs1800469-T and AGTR1 rs12695895-T might be associated with increased risk of AAA. The complex gene gene and gene environment interactions. might contribute to the risk of AAA. As a small study, the preliminary results need extensive validation and replication in larger populations. (C) 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000357705900011
通讯作者邮箱yhhu@bjmu.edu.cn
项目编号81230066 ; 09BJZ04
资助机构National Natural Science Foundation of China ; Health Care Foundation of PLA
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60838
专题北京大学公共卫生学院
北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Vasc & Endovasc Surg, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zuo, S.,Xiong, J.,Wei, Y.,et al. Potential Interactions Between Genetic Polymorphisms of the Transforming Growth Factor-beta Pathway and Environmental Factors in Abdominal Aortic Aneurysms[J]. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY,2015,50(1):71-77.
APA Zuo, S..,Xiong, J..,Wei, Y..,Chen, D..,Chen, F..,...&Guo, W..(2015).Potential Interactions Between Genetic Polymorphisms of the Transforming Growth Factor-beta Pathway and Environmental Factors in Abdominal Aortic Aneurysms.EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY,50(1),71-77.
MLA Zuo, S.,et al."Potential Interactions Between Genetic Polymorphisms of the Transforming Growth Factor-beta Pathway and Environmental Factors in Abdominal Aortic Aneurysms".EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 50.1(2015):71-77.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zuo, S.]的文章
[Xiong, J.]的文章
[Wei, Y.]的文章
百度学术
百度学术中相似的文章
[Zuo, S.]的文章
[Xiong, J.]的文章
[Wei, Y.]的文章
必应学术
必应学术中相似的文章
[Zuo, S.]的文章
[Xiong, J.]的文章
[Wei, Y.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。