北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea
作者: Liu, Hong; Yang, Fan; Li, Zhiping; Chen, Changzhong; Fang, Zhian; Wang, Lihua; Hu, Yonghua; Chen, Dafang
关键词: cytochrome P-450CYP1A1 ; dysmenorrhea ; polymorphism ; genetic ; tobacco smoke pollution
刊名: REPRODUCTIVE TOXICOLOGY
发表日期: 2007-07-01
DOI: 10.1016/j.reprotox.2007.04.069
卷: 24, 期:1, 页:114-119
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Reproductive Biology ; Toxicology
研究领域[WOS]: Reproductive Biology ; Toxicology
关键词[WOS]: CIGARETTE-SMOKING ; TOBACCO-SMOKE ; YOUNG-WOMEN ; RISK ; ASSOCIATION ; SEVERITY ; WEIGHT ; CANCER ; PAIN ; DNA
英文摘要:

Objective: This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1 MspI and CYP1A1HincII.

Methods: This report includes 1645 (1124 no dysmenorrhea, 521 dysmenorrhea) nonsmoking and nondrinking newly wed female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for perceived stress.

Results: When stratified by women genotype, the adjusted OR of dysmenorrhea was 1.6 (95%CI = 1.3-2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95%CI = 1.1-2.1) with C/C6235 genotype, compared to nonpassive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 MspI C/C6235 and HincII Ile/Ile462 genotype (OR = 2.6, 95%CI = 1.3-5.2).

Conclusion: CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000248775200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60840
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA 02115 USA

Recommended Citation:
Liu, Hong,Yang, Fan,Li, Zhiping,et al. Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea[J]. REPRODUCTIVE TOXICOLOGY,2007,24(1):114-119.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Hong]'s Articles
[Yang, Fan]'s Articles
[Li, Zhiping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Hong]‘s Articles
[Yang, Fan]‘s Articles
[Li, Zhiping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace