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学科主题: 基础医学
题名:
NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement
作者: Ma, Yao-Ying; Chu, Ning-Ning; Guo, Chang-Yong; Han, Ji-Sheng; Cui, Cai-Lian
关键词: conditioned place preference ; morphine ; nucleus accumbens ; hippocampus ; forced swim ; food deprivation ; rats
刊名: EXPERIMENTAL NEUROLOGY
发表日期: 2007-02-01
DOI: 10.1016/j.expneurol.2006.08.014
卷: 203, 期:2, 页:309-319
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING BEHAVIOR ; CORTICOTROPIN-RELEASING-FACTOR ; ANXIETY-LIKE BEHAVIOR ; PREFRONTAL CORTEX ; FOOD-DEPRIVATION ; INDUCED RELAPSE ; NEUROPSYCHIATRIC DISORDERS ; LASTING INCREASES ; NUCLEUS-ACCUMBENS
英文摘要:

Glutamate receptors are known to be densely distributed in the forebrain rewarding circuits, and glutamatergic transmission is actively involved in the regulation of rewarding and reinstating effects of drugs of abuse. Here we investigated the possible involvement of the N-methylD-aspartate (NMDA) receptors in the reinstatement of extinguished morphine conditioned place preference (CPP) in rats. We found that previously extinguished morphine (3 mg/kg, i.p.) CPP was markedly reinstated by a priming injection of morphine (2 mg/kg, i.p.) or an acute environmental stressor (forced swim for 10 min), but not by the stress induced by a 24-h food deprivation. Parallel with this, protein levels of the NMDA receptor 2B subunit (NR2B) were elevated in the nucleus accumbens (NAc) and the hippocampus, but not the prefrontal cortex, of reinstated rats. Systemic administration of an NR2B selective antagonist ifenprodil 3, 10 mg/kg, i.p.) attenuated the reinstatement induced by a priming morphine injection, although not by the forced swim. Ifenprodil (2.0 mu g/rat) directly injected into the NAc shell or the CA 1 region of the dorsal hippocampus produced a similar effect. These results indicate that the NR2B-containing NMDA receptors in the NAc and the dorsal hippocampus play a significant role in mediating the reinstatement of rewarding responses to morphine. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000244046000004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60842
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Ma, Yao-Ying,Chu, Ning-Ning,Guo, Chang-Yong,et al. NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement[J]. EXPERIMENTAL NEUROLOGY,2007,203(2):309-319.
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