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学科主题基础医学
NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement
Ma, Yao-Ying; Chu, Ning-Ning; Guo, Chang-Yong; Han, Ji-Sheng; Cui, Cai-Lian
关键词Conditioned Place Preference Morphine Nucleus Accumbens Hippocampus Forced Swim Food Deprivation Rats
刊名EXPERIMENTAL NEUROLOGY
2007-02-01
DOI10.1016/j.expneurol.2006.08.014
203期:2页:309-319
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING BEHAVIOR ; CORTICOTROPIN-RELEASING-FACTOR ; ANXIETY-LIKE BEHAVIOR ; PREFRONTAL CORTEX ; FOOD-DEPRIVATION ; INDUCED RELAPSE ; NEUROPSYCHIATRIC DISORDERS ; LASTING INCREASES ; NUCLEUS-ACCUMBENS
英文摘要

Glutamate receptors are known to be densely distributed in the forebrain rewarding circuits, and glutamatergic transmission is actively involved in the regulation of rewarding and reinstating effects of drugs of abuse. Here we investigated the possible involvement of the N-methylD-aspartate (NMDA) receptors in the reinstatement of extinguished morphine conditioned place preference (CPP) in rats. We found that previously extinguished morphine (3 mg/kg, i.p.) CPP was markedly reinstated by a priming injection of morphine (2 mg/kg, i.p.) or an acute environmental stressor (forced swim for 10 min), but not by the stress induced by a 24-h food deprivation. Parallel with this, protein levels of the NMDA receptor 2B subunit (NR2B) were elevated in the nucleus accumbens (NAc) and the hippocampus, but not the prefrontal cortex, of reinstated rats. Systemic administration of an NR2B selective antagonist ifenprodil 3, 10 mg/kg, i.p.) attenuated the reinstatement induced by a priming morphine injection, although not by the forced swim. Ifenprodil (2.0 mu g/rat) directly injected into the NAc shell or the CA 1 region of the dorsal hippocampus produced a similar effect. These results indicate that the NR2B-containing NMDA receptors in the NAc and the dorsal hippocampus play a significant role in mediating the reinstatement of rewarding responses to morphine. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000244046000004
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60842
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Ma, Yao-Ying,Chu, Ning-Ning,Guo, Chang-Yong,et al. NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement[J]. EXPERIMENTAL NEUROLOGY,2007,203(2):309-319.
APA Ma, Yao-Ying,Chu, Ning-Ning,Guo, Chang-Yong,Han, Ji-Sheng,&Cui, Cai-Lian.(2007).NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement.EXPERIMENTAL NEUROLOGY,203(2),309-319.
MLA Ma, Yao-Ying,et al."NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement".EXPERIMENTAL NEUROLOGY 203.2(2007):309-319.
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