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学科主题: 临床医学
题名:
A Quantitative Study of the Relationship between the Distribution of Different Types of Collagen and the Mechanical Behavior of Rabbit Medial Collateral Ligaments
作者: Wan, Chao1; Hao, Zhixiu1; Wen, Shizhu1; Leng, Huijie2
刊名: PLOS ONE
发表日期: 2014-07-25
DOI: 10.1371/journal.pone.0103363
卷: 9, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ANTERIOR CRUCIATE LIGAMENT ; PATELLAR TENDON ; PICROSIRIUS-POLARIZATION ; BIOMECHANICAL PROPERTIES ; CONNECTIVE-TISSUE ; MODEL ; STRESS ; MICROSCOPY ; DIAMETER ; REPAIR
英文摘要:

The mechanical properties of ligaments are key contributors to the stability and function of musculoskeletal joints. Ligaments are generally composed of ground substance, collagen (mainly type I and III collagen), and minimal elastin fibers. However, no consensus has been reached about whether the distribution of different types of collagen correlates with the mechanical behaviors of ligaments. The main objective of this study was to determine whether the collagen type distribution is correlated with the mechanical properties of ligaments. Using axial tensile tests and picrosirius red staining-polarization observations, the mechanical behaviors and the ratios of the various types of collagen were investigated for twenty-four rabbit medial collateral ligaments from twenty-four rabbits of different ages, respectively. One-way analysis of variance was used in the comparison of the Young′s modulus in the linear region of the stress-strain curves and the ratios of type I and III collagen for the specimens (the mid-substance specimens of the ligaments) with different ages. A multiple linear regression was performed using the collagen contents (the ratios of type I and III collagen) and the Young′s modulus of the specimens. During the maturation of the ligaments, the type I collagen content increased, and the type III collagen content decreased. A significant and strong correlation (R-2 = 0: 839, P < 0.05) was identified by multiple linear regression between the collagen contents (i. e., the ratios of type I and type III collagen) and the mechanical properties of the specimens. The collagen content of ligaments might provide a new perspective for evaluating the linear modulus of global stress-strain curves for ligaments and open a new door for studying the mechanical behaviors and functions of connective tissues.

语种: 英语
所属项目编号: 51275267 ; 11002004
项目资助者: Science Foundation of China
WOS记录号: WOS:000339992600062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60848
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Tsinghua Univ, State Key Lab Tribol, Beijing 100084, Peoples R China
2.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Wan, Chao,Hao, Zhixiu,Wen, Shizhu,et al. A Quantitative Study of the Relationship between the Distribution of Different Types of Collagen and the Mechanical Behavior of Rabbit Medial Collateral Ligaments[J]. PLOS ONE,2014,9(7).
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