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A Quantitative Study of the Relationship between the Distribution of Different Types of Collagen and the Mechanical Behavior of Rabbit Medial Collateral Ligaments
Wan, Chao1; Hao, Zhixiu1; Wen, Shizhu1; Leng, Huijie2
刊名PLOS ONE
2014-07-25
DOI10.1371/journal.pone.0103363
9期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ANTERIOR CRUCIATE LIGAMENT ; PATELLAR TENDON ; PICROSIRIUS-POLARIZATION ; BIOMECHANICAL PROPERTIES ; CONNECTIVE-TISSUE ; MODEL ; STRESS ; MICROSCOPY ; DIAMETER ; REPAIR
英文摘要

The mechanical properties of ligaments are key contributors to the stability and function of musculoskeletal joints. Ligaments are generally composed of ground substance, collagen (mainly type I and III collagen), and minimal elastin fibers. However, no consensus has been reached about whether the distribution of different types of collagen correlates with the mechanical behaviors of ligaments. The main objective of this study was to determine whether the collagen type distribution is correlated with the mechanical properties of ligaments. Using axial tensile tests and picrosirius red staining-polarization observations, the mechanical behaviors and the ratios of the various types of collagen were investigated for twenty-four rabbit medial collateral ligaments from twenty-four rabbits of different ages, respectively. One-way analysis of variance was used in the comparison of the Young′s modulus in the linear region of the stress-strain curves and the ratios of type I and III collagen for the specimens (the mid-substance specimens of the ligaments) with different ages. A multiple linear regression was performed using the collagen contents (the ratios of type I and III collagen) and the Young′s modulus of the specimens. During the maturation of the ligaments, the type I collagen content increased, and the type III collagen content decreased. A significant and strong correlation (R-2 = 0: 839, P < 0.05) was identified by multiple linear regression between the collagen contents (i. e., the ratios of type I and type III collagen) and the mechanical properties of the specimens. The collagen content of ligaments might provide a new perspective for evaluating the linear modulus of global stress-strain curves for ligaments and open a new door for studying the mechanical behaviors and functions of connective tissues.

语种英语
WOS记录号WOS:000339992600062
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60848
专题北京大学第三临床医学院_骨科
作者单位1.Tsinghua Univ, State Key Lab Tribol, Beijing 100084, Peoples R China
2.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wan, Chao,Hao, Zhixiu,Wen, Shizhu,et al. A Quantitative Study of the Relationship between the Distribution of Different Types of Collagen and the Mechanical Behavior of Rabbit Medial Collateral Ligaments[J]. PLOS ONE,2014,9(7).
APA Wan, Chao,Hao, Zhixiu,Wen, Shizhu,&Leng, Huijie.(2014).A Quantitative Study of the Relationship between the Distribution of Different Types of Collagen and the Mechanical Behavior of Rabbit Medial Collateral Ligaments.PLOS ONE,9(7).
MLA Wan, Chao,et al."A Quantitative Study of the Relationship between the Distribution of Different Types of Collagen and the Mechanical Behavior of Rabbit Medial Collateral Ligaments".PLOS ONE 9.7(2014).
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