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学科主题: 临床医学
题名:
Differences in Baseline Dark and the Dark-to-Light Changes in Anterior Chamber Angle Parameters in Whites and Ethnic Chinese
作者: Wang, Dandan1,2; Chiu, Cynthia1; He, Mingguang2; Wu, Lingling3; Kao, Andrew1; Lin, Shan1
刊名: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
发表日期: 2011-12-01
DOI: 10.1167/iovs.11-8470
卷: 52, 期:13, 页:9404-9410
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: OPTICAL COHERENCE TOMOGRAPHY ; CLOSURE GLAUCOMA ; LIWAN EYE ; IRIS ; POPULATION ; GONIOSCOPY ; SUSPECTS ; BIOMETRY ; PEOPLE ; IMAGES
英文摘要:

PURPOSE. To assess the anterior chamber drainage angle width in the dark and the dark-to-light change (Delta) between Caucasians and Chinese aged 40 years and older.

METHODS. The study groups comprised four age-and sexmatched cohorts: American Caucasians, American Chinese, southern mainland Chinese, and northern mainland Chinese. Anterior segment optical coherence tomography (ASOCT) images of the anterior chamber angles were obtained under both light and dark conditions. The parameters analyzed included angle opening distance (AOD), angle recess area (ARA), and trabecular-iris space area (TISA).

RESULTS. Data were obtained from 121, 124, 121, and 120 participants who were American Caucasians, American Chinese, and southern and northern mainland Chinese, respectively. In a multiple linear regression analysis, adjusted for age, sex, refractive status, pupil size, lens location, and anterior chamber depth (ACD) and width (ACW), the ethnic Chinese had significantly smaller ARAs (regression coefficient, beta = -0.06, P < 0.001) and TISAs (beta = -0.01, P = 0.039), as well as greater Delta AODs (beta = 0.03, P = 0.009) and Delta TISAs (beta = 0.02, P = 0.029) than did the Caucasians. For the dark-to-light change analysis, the independent associations between angle width and iris thickness (IT) and iris curvature (ICurv) were identified only in the Chinese.

CONCLUSIONS. Compared with the Caucasians, the ethnic Chinese had smaller ARA and TISA, but greater dark-to-light changes in AOD and TISA, independent of refractive status and overall ocular anterior segment dimensions. (Invest Ophthalmol Vis Sci. 2011; 52: 9404-9410) DOI: 10.1167/iovs.11-8470

语种: 英语
所属项目编号: EY002161
项目资助者: George and Rosalie Hearst Foreign Fellowship ; That Man May See, Inc. ; Research to Prevent Blindness ; National Eye Institute Core
WOS记录号: WOS:000298628200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60851
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA
2.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Guangdong, Peoples R China
3.Peking Univ, Hosp 3, Ctr Eye, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Dandan,Chiu, Cynthia,He, Mingguang,et al. Differences in Baseline Dark and the Dark-to-Light Changes in Anterior Chamber Angle Parameters in Whites and Ethnic Chinese[J]. INVESTIGATIVE OPHTHALMOLOGY &amp; VISUAL SCIENCE,2011,52(13):9404-9410.
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