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学科主题: 药物依赖
题名:
Glycogen synthase kinase-3 beta in the ventral tegmental area mediates diurnal variations in cocaine-induced conditioned place preference in rats
作者: Li, Su-Xia1; Wei, Yi-Ming2; Shi, Hai-Shui1; Luo, Yi-Xiao1; Ding, Zeng-Bo1; Xue, Yan-Xue1; Lu, Lin1; Yu, Chang-Xi3
关键词: Cocaine ; conditioned place preference ; diurnal rhythm ; GSK-3 beta ; SB216763
刊名: ADDICTION BIOLOGY
发表日期: 2014-11-01
DOI: 10.1111/adb.12068
卷: 19, 期:6, 页:996-1005
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Substance Abuse
研究领域[WOS]: Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]: MAMMALIAN CIRCADIAN CLOCK ; BEHAVIORAL SENSITIZATION ; OPIATE WITHDRAWAL ; REWARD ; TIME ; EXPRESSION ; RHYTHMS ; PROTEIN ; GENES ; AMYGDALA
英文摘要:

Cocaine sensitization and reward are reported to be under the influence of diurnal rhythm. However, no previous studies have reported brain areas that play a role as modulators and underlie the mechanism of diurnal variations in cocaine reward. We examined (1) the diurnal rhythm of glycogen synthase kinase-3 beta (GSK-3 beta) activity in the suprachiasmatic nucleus (SCN) and reward-related brain areas in naive rats; (2) the effect of day and night on the acquisition of cocaine-induced conditioned place preference (CPP); (3) the influence of cocaine-induced CPP on GSK-3 beta activity in the SCN and reward-related brain areas; and (4) the effect of the GSK-3 beta inhibitor SB216763 microinjected bilaterally into the ventral tegmental area (VTA) on cocaine-induced CPP. A significant diurnal rhythm of GSK-3 beta activity was found in the SCN and reward-related brain areas, with diurnal variations in cocaine-induced CPP. GSK-3 beta activity in the SCN and reward-related brain areas exhibited marked diurnal variations in rats treated with saline. GSK-3 beta activity in rats treated with cocaine exhibited distinct diurnal variations only in the prefrontal cortex and VTA. Cocaine decreased the expression of phosphorylated GSK-3 beta (i.e. increased GSK-3 beta activity) only in the VTA in rats trained and tested at ZT4 and ZT16. SB216763 microinjected into the VTA bilaterally eliminated the diurnal variations in cocaine-induced CPP, but did not affect the acquisition of cocaine-induced CPP. These findings suggest that the VTA may be a critical area involved in the diurnal variations in cocaine-induced CPP, and GSK-3 beta may be a regulator of diurnal variations in cocaine-induced CPP.

语种: 英语
所属项目编号: 20090001120132 ; 2010J01174 ; JK2010026
项目资助者: Department of Education of China ; Natural Science Foundation of Fujian Province ; Special Fund for Provincial University of Fujian Provincial Department of Education
WOS记录号: WOS:000345842100005
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60852
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Fujian Med Univ, Inst Basic Med, Fuzhou, Peoples R China
2.Fujian Med Univ, Coll Pharm, Fuzhou, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Li, Su-Xia,Wei, Yi-Ming,Shi, Hai-Shui,et al. Glycogen synthase kinase-3 beta in the ventral tegmental area mediates diurnal variations in cocaine-induced conditioned place preference in rats[J]. ADDICTION BIOLOGY,2014,19(6):996-1005.
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