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学科主题: 临床医学
题名:
The sho1 sensor regulates growth, morphology, and oxidant adaptation in Aspergillus fumigatus but is not essential for development of invasive pulmonary aspergillosis
作者: Ma, Yan1,2; Qiao, Jianjun1,2; Liu, Wei1,2; Wan, Zhe1,2; Wang, Xiaohong1,2; Calderone, Richard3; Li, Ruoyu1,2
刊名: INFECTION AND IMMUNITY
发表日期: 2008-04-01
DOI: 10.1128/IAI.01507-07
卷: 76, 期:4, 页:1695-1701
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases
研究领域[WOS]: Immunology ; Infectious Diseases
关键词[WOS]: MOUSE INFECTION MODEL ; CANDIDA-ALBICANS ; OXIDATIVE STRESS ; AGROBACTERIUM-TUMEFACIENS ; SACCHAROMYCES-CEREVISIAE ; MEDIATED TRANSFORMATION ; PROTEIN-KINASE ; EXTRA COPIES ; VIRULENCE ; GENE
英文摘要:

Aspergillus fumigatus is an important opportunistic fungal pathogen. This organism must be able to adapt to stress changes in the microenvironment during host invasion and systemic spread. The high-osmolarity-glycerol (HOG) mitogen-activated protein kinase (HOG-MAPK) signaling pathway plays an important role in regulating morphology, growth, and adaptation to stress and virulence in a number of fungal pathogens. The Sho1 adaptor protein is one important element of the two upstream branches of the HOG-MAPK pathway in Saccharomyces cerevisiae, a signal transduction cascade involved in adaptation to stress. We constructed a sho1 mutant of A. fumigatus, MA21. Both the growth and germination rates of the mutant were reduced, and the MA21 strain had an irregular hyphal morphology characterized by reduced production of phialides and conidia. This gene deletion mutant was sensitive to 2.5 mM hydrogen peroxide and 15 mu M menadione, but it appeared to be minimally sensitive to diamide compared to the wild-type strain. In an immunosuppressed mouse model, the mutant was as virulent as the wild-type or complemented strains. These data support the idea that the loss of sho1, a highly conserved gene among fungi, regulates radial hyphal growth and delays germination of A. fumigatus conidia. In addition, the sho1 gene has a visible effect in the adaptation to oxidative stress in A. fumigatus similar to that in S. cerevisiae.

语种: 英语
WOS记录号: WOS:000254725700038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60853
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, Res Ctr Med Mycol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
3.Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Washington, DC 20057 USA

Recommended Citation:
Ma, Yan,Qiao, Jianjun,Liu, Wei,et al. The sho1 sensor regulates growth, morphology, and oxidant adaptation in Aspergillus fumigatus but is not essential for development of invasive pulmonary aspergillosis[J]. INFECTION AND IMMUNITY,2008,76(4):1695-1701.
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