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Beneficial Effect of Erythropoietin on Sensorimotor Function and White Matter After Hypoxia-Ischemia in Neonatal Mice
Fan, Xiyong1,2,3; Heijnen, Cob J.2; van der Kooij, Michael A.1,2; Groenendaal, Floris1; van Bel, Frank1
刊名PEDIATRIC RESEARCH
2011
69期:1页:56-61
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
研究领域[WOS]Pediatrics
关键词[WOS]DOSE RECOMBINANT ERYTHROPOIETIN ; BRAIN-INJURY ; NEUROLOGICAL FUNCTION ; PRETERM INFANTS ; IN-VITRO ; RATS ; NEUROPROTECTION ; STROKE ; HYPOXIA/ISCHEMIA ; NEUROGENESIS
英文摘要

There are mixed reports on the neuroprotective properties of erythropoietin (EPO) in animal models of birth asphyxia. We investigated the effect of EPO on short- and long-term outcome after neonatal hypoxic-ischemic (HI) brain injury in mice and compared the effect of two different dose regimens of EPO. Nine-day-old mice were subjected to HI, and EPO was injected i.p. at 0, 24, and 48 h after HI in a dose of either 5 or 20 kU/kg. Paw preference in the cylinder rearing test (CRT) was used as a measure of sensorimotor function. Only in female mice, administration of EPO at 5 kU/kg but not 20 kU/kg improved sensorimotor function, reduced striatum atrophy and hippocampal lesion volume, and enhanced myelin basic protein (MBP) staining as determined at 4 and 9 wk after HI. In addition, at 72 h after HI, more Ki67 cells were found in the subventricular zone and dentate gyrus after EPO 5 kU/kg treatment, indicating an increase in progenitor cell proliferation. In conclusion, EPO improves sensorimotor function after neonatal HI and protects against striatum atrophy, hippocampus injury, and white matter loss. The protective effect of EPO is dose-dependent and only present in females. (Pediatr Res 69: 56-61, 2011)

语种英语
WOS记录号WOS:000285679000012
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被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60855
专题北京大学第一临床医学院_儿科
作者单位1.Univ Med Ctr Utrecht, Dept Neonatol, NL-3584 EA Utrecht, Netherlands
2.Univ Med Ctr Utrecht, Lab Neuroimmunol & Dev Origins Dis NIDOD, NL-3584 EA Utrecht, Netherlands
3.Peking Univ, Hosp 1, Dept Paediat, Beijing 100034, Peoples R China
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Fan, Xiyong,Heijnen, Cob J.,van der Kooij, Michael A.,et al. Beneficial Effect of Erythropoietin on Sensorimotor Function and White Matter After Hypoxia-Ischemia in Neonatal Mice[J]. PEDIATRIC RESEARCH,2011,69(1):56-61.
APA Fan, Xiyong,Heijnen, Cob J.,van der Kooij, Michael A.,Groenendaal, Floris,&van Bel, Frank.(2011).Beneficial Effect of Erythropoietin on Sensorimotor Function and White Matter After Hypoxia-Ischemia in Neonatal Mice.PEDIATRIC RESEARCH,69(1),56-61.
MLA Fan, Xiyong,et al."Beneficial Effect of Erythropoietin on Sensorimotor Function and White Matter After Hypoxia-Ischemia in Neonatal Mice".PEDIATRIC RESEARCH 69.1(2011):56-61.
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