北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis
作者: Zhang, Ai-Hua; Chen, Min; Gao, Ying; Zhao, Ming-Hui; Wang, Hai-Yan
关键词: prophylthiouracil ; ANCA ; myeloperoxidase ; microscopic polyangiitis ; oxidation activity
刊名: CLINICAL IMMUNOLOGY
发表日期: 2007-02-01
DOI: 10.1016/j.clim.2006.09.011
卷: 122, 期:2, 页:187-193
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: PRIMARY BILIARY-CIRRHOSIS ; RAT BONE-MARROW ; ANTIMYELOPEROXIDASE ANTIBODIES ; ANCA ; AUTOANTIBODIES ; NEUTROPHILS ; PROTEINASE-3 ; PEROXIDASES ; INVITRO ; DRUGS
英文摘要:

Propylthiouracil (PTU) could induce antineutrophil cytoplasmic antibody (ANCA) associated vasculitis. This study aimed to investigate the inhibitory effects on MPO oxidation activity by PTU and MPO-ANCA from patients with primary microscopic potyangiitis (MPA) and PTU-induced vasculitis. IgG preparations were purified from MPO-ANCA-positive sera from seven patients with PTU-induced vasculitis and ten patients with primary MPA. The oxidation activity of MPO was measured in the presence of PTU and MPC-ANCA-positive IgG preparations from patients with PTU-induced vasculitis and primary MPA respectively. PTU could competitively inhibit the oxidation activity of MPO dose dependently. MPO-ANCA-positive IgG preparations from 6/7 patients with PTU-induced vasculitis and only 3/10 from patients with primary MPA could inhibit the MPO activity in a dose-dependent manner. In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPC-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000243779300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60856
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, First Hosp, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Ai-Hua,Chen, Min,Gao, Ying,et al. Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis[J]. CLINICAL IMMUNOLOGY,2007,122(2):187-193.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Ai-Hua]'s Articles
[Chen, Min]'s Articles
[Gao, Ying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Ai-Hua]‘s Articles
[Chen, Min]‘s Articles
[Gao, Ying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace