IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis
Zhang, Ai-Hua; Chen, Min; Gao, Ying; Zhao, Ming-Hui; Wang, Hai-Yan
关键词prophylthiouracil ANCA myeloperoxidase microscopic polyangiitis oxidation activity
刊名CLINICAL IMMUNOLOGY
2007-02-01
DOI10.1016/j.clim.2006.09.011
122期:2页:187-193
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]PRIMARY BILIARY-CIRRHOSIS ; RAT BONE-MARROW ; ANTIMYELOPEROXIDASE ANTIBODIES ; ANCA ; AUTOANTIBODIES ; NEUTROPHILS ; PROTEINASE-3 ; PEROXIDASES ; INVITRO ; DRUGS
英文摘要

Propylthiouracil (PTU) could induce antineutrophil cytoplasmic antibody (ANCA) associated vasculitis. This study aimed to investigate the inhibitory effects on MPO oxidation activity by PTU and MPO-ANCA from patients with primary microscopic potyangiitis (MPA) and PTU-induced vasculitis. IgG preparations were purified from MPO-ANCA-positive sera from seven patients with PTU-induced vasculitis and ten patients with primary MPA. The oxidation activity of MPO was measured in the presence of PTU and MPC-ANCA-positive IgG preparations from patients with PTU-induced vasculitis and primary MPA respectively. PTU could competitively inhibit the oxidation activity of MPO dose dependently. MPO-ANCA-positive IgG preparations from 6/7 patients with PTU-induced vasculitis and only 3/10 from patients with primary MPA could inhibit the MPO activity in a dose-dependent manner. In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPC-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000243779300010
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60856
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, First Hosp, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Inst Nephrol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Ai-Hua,Chen, Min,Gao, Ying,et al. Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis[J]. CLINICAL IMMUNOLOGY,2007,122(2):187-193.
APA Zhang, Ai-Hua,Chen, Min,Gao, Ying,Zhao, Ming-Hui,&Wang, Hai-Yan.(2007).Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis.CLINICAL IMMUNOLOGY,122(2),187-193.
MLA Zhang, Ai-Hua,et al."Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis".CLINICAL IMMUNOLOGY 122.2(2007):187-193.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Ai-Hua]的文章
[Chen, Min]的文章
[Gao, Ying]的文章
百度学术
百度学术中相似的文章
[Zhang, Ai-Hua]的文章
[Chen, Min]的文章
[Gao, Ying]的文章
必应学术
必应学术中相似的文章
[Zhang, Ai-Hua]的文章
[Chen, Min]的文章
[Gao, Ying]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。