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学科主题: 药学
题名:
Development and pharmacokinetics of nimodipine-loaded liposomes
作者: Wang, Zhixuan; Deng, Yingjie; Zhang, Xiaopeng; Wang, Ting; Wu, Fenglan
刊名: JOURNAL OF PHARMACY AND PHARMACOLOGY
发表日期: 2006-09-01
DOI: 10.1211/jpp.58.9.0017
卷: 58, 期:9, 页:1289-1294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要:

In order to improve the water solubility of nimodipine and prolong the time of the drug in the circulation, nimodipine-loaded liposomes with a small size and high entrapment efficiency were prepared by a method that was easy to scale up (the modified ethanol injection method). The nimodipine liposome dispersions were characterized with respect to particle size distribution, zeta potential and entrapment efficiency. Liposomal nimodipine and nimodipine solution were intravenously administered to mice as a single dose of 4 mg kg(-1). The pharmacokinetic parameters of nimodipine changed significantly when encapsulated in liposomes. The clearance of nimodipine encapsulated in liposomes was reduced and the elimination half-life was prolonged. The ratios of the area under the curve values of nimodipine liposomes to nimodipine solution were 1.78 and 1.90 in plasma and cerebral tissue, respectively. The drug concentration in cerebral tissue and in plasma showed a good linear correlation, which showed that liposomes could efficiently deliver nimodipine into brain tissue. These findings suggest that intravenous administration of liposomal nimodipine produces higher and more stable plasma and cerebral drug concentrations compared with nimodipine solution. In conclusion, liposomal nimodipine is a promising alternative to the solution preparation.

语种: 英语
WOS记录号: WOS:000240582800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60860
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Dept Pharmaceut Sci, Shenyang 110016, Liaoning Prov, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Zhixuan,Deng, Yingjie,Zhang, Xiaopeng,et al. Development and pharmacokinetics of nimodipine-loaded liposomes[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2006,58(9):1289-1294.
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