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学科主题: 临床医学
题名:
Breast cancer subtypes and survival in Chinese women with operable primary breast cancer
作者: Li, Zhao-sheng1; Yao, Lu1; Liu, Yi-qiang2; Ouyang, Tao1; Li, Jin-feng1; Wang, Tian-feng1; Fan, Zhao-qing1; Fan, Tie1; Lin, Ben-Yao1; Xie, Yun-tao1
关键词: Breast cancer ; Subtypes ; Disease-free survival ; Overall survival
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2011-06-01
DOI: 10.1007/s11670-011-0134-z
卷: 23, 期:2, 页:134-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MOLECULAR SUBTYPES ; EXPRESSION ; HER-2
英文摘要:

To investigate the associations between the different breast cancer subtypes and survival in Chinese women with operable primary breast cancer.

A total of 1538 Chinese women with operable primary breast cancer were analyzed in this study, the median follow-up was 77 months. Estrogen receptor (ER), progesterone receptor (PR), and HER2 status were available for these patients.

Luminal A (ER+ and/or PR+, HER2-) had a favorable disease-free survival (DFS) and overall survival (OS) compared with other subtypes in the entire cohort. Using the luminal A as a reference, among the patients with lymph node positive disease, HER2+ (ER-, PR-, HER2+) had the worst DFS (hazard ratio, HR=1.80, 95% CI 1.11 to 2.91, P=0.017) and luminal B (ER+ and/or PR+, HER2+) had the worst OS (HR=2.27, 95% CI 1.50 to 3.45, P < 0.001); among the patients with lymph node negative disease, triple-negative (ER-, PR-, HER2-) had the worst DFS (HR=2.21, 95% CI 1.43 to 3.41, P < 0.001), whereas no significant difference in DFS between HER2+ and luminal B or luminal A was observed.

As compared with luminal A, luminal B and HER2+ have the worst survival in patients with lymph node positive disease, but this is not the case in patients with lymph node negative disease; triple-negative subtype has a worse survival in both lymph node positive and lymph node negative patients.

语种: 英语
所属项目编号: 30973436
项目资助者: Program fro Breast Cancer Tissue Bank of Beijing ; National Natural Science Foundation of China
WOS记录号: WOS:000290804600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60863
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Breast Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Li, Zhao-sheng,Yao, Lu,Liu, Yi-qiang,et al. Breast cancer subtypes and survival in Chinese women with operable primary breast cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2011,23(2):134-139.
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