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学科主题: 临床医学
题名:
Bridging peripheral nerves using a deacetyl chitin conduit combined with short-term electrical stimulation
作者: Zhang, Zhongli1; Li, Xin2; Zuo, Songjie3; Xin, Jie1; Zhang, Peixun4
关键词: nerve regeneration ; peripheral nerve injury ; deacetyl chitin conduit ; electrical stimulation ; NSFC grant ; neural regeneration
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2014-05-01
DOI: 10.4103/1673-5374.133168
卷: 9, 期:10, 页:1075-1078
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: FUNCTIONAL RECOVERY ; SMALL-GAP ; INJURY ; OUTGROWTH
英文摘要:

Previous studies have demonstrated that deacetyl chitin conduit nerve bridging or electrical stimulation can effectively promote the regeneration of the injured peripheral nerve. We hypothesized that the combination of these two approaches could result in enhanced regeneration. Rats with right sciatic nerve injury were subjected to deacetyl chitin conduit bridging combined with electrical stimulation (0.1 ms, 3 V, 20 Hz, for 1 hour). At 6 and 12 weeks after treatment, nerve conduction velocity, myelinated axon number, fiber diameter, axon diameter and the thickness of the myelin sheath in the stimulation group were better than in the non-stimulation group. The results indicate that deacetyl chitin conduit bridging combined with temporary electrical stimulation can promote peripheral nerve repair.

语种: 英语
所属项目编号: 2014CB542200 ; 31171150 ; 31271284 ; 30801169 ; BMU20110270 ; 2008A010 ; 20070001780
项目资助者: National Program on Key Basic Research Project of China (973 Program) ; National Natural Science Foundation of China ; Chinese Educational Ministry New Century Excellent Talent Support Project ; Beijing City Science &amp ; Technology New Star Classification ; Ministry of Education New Teachers of Institutions of Higher Learning Doctoral Fund
WOS记录号: WOS:000337068800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60865
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Weifang Med Coll, Dept Physiol, Weifang, Shandong, Peoples R China
2.Weifang Peoples Hosp, Dept Traumat Orthoped, Weifang, Shandong, Peoples R China
3.Chinese Ctr Dis Prevent & Control, Natl Inst Radiol Protect, Beijing, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Zhongli,Li, Xin,Zuo, Songjie,et al. Bridging peripheral nerves using a deacetyl chitin conduit combined with short-term electrical stimulation[J]. NEURAL REGENERATION RESEARCH,2014,9(10):1075-1078.
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