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学科主题: 临床医学
题名:
Effect of Metformin on Cancer Risk and Treatment Outcome of Prostate Cancer: A Meta-Analysis of Epidemiological Observational Studies
作者: Yu, Hongliang1,2; Yin, Li1,2; Jiang, Xuesong1,2; Sun, Xiujin1,2; Wu, Jing1,2; Tian, Hao1,2; Gao, Xianshu3; He, Xia1,2
刊名: PLOS ONE
发表日期: 2014-12-29
DOI: 10.1371/journal.pone.0116327
卷: 9, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DIABETIC-PATIENTS ; INCIDENT CANCER ; CLINICAL-TRIALS ; BREAST-CANCER ; SULFONYLUREA ; MORTALITY ; COHORT ; SURVIVAL ; IMPACT ; BIAS
英文摘要:

Background: Laboratory studies have shown the anti-tumor effect of metformin on prostate cancer. However, recent epidemiological studies have yielded inconclusive results.

Methods: We searched PubMed database from the inception to May 30 2014 for studies which assessed the effect of metformin use on cancer risk of prostate cancer, biochemical recurrence (BCR) and all-cause mortality of patients with prostate cancer. The pooled results and 95% confidence intervals (CIs) were estimated by random-effect model.

Results: Twenty-one studies were eligible according to the inclusion criteria. Based on the pooled results of available observational studies, metformin use was significantly associated with a decreased cancer risk (14 datasets, 963991 male subjects, odds ratio: 0.91, 95% CI: 0.85-0.97) and BCR (6 datasets, 2953 patients, hazard ratio: 0.81, 95% CI: 0.68-0.98) of prostate cancer. However, the association of metformin use with all-cause mortality of patients with prostate cancer was not significant (5 datasets, 9241 patients, hazard ratio: 0.86, 95% CI: 0.64-1.14).

Conclusion: Results suggest that metformin use appears to be associated with a significant reduction in the cancer risk and BCR of prostate cancer, but not in all-cause mortality of patients with prostate cancer.

语种: 英语
所属项目编号: BK20141018 ; BRA2013292 ; WS-047 ; 30670619 ; 81072017
项目资助者: Jiangsu Provincial Natural Science Fund ; "333" Project of Jiangsu Province ; Six Major Talent Peak Project of Jiangsu Province ; Natural Science Foundation of China
WOS记录号: WOS:000347120200112
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60868
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Canc Hosp, Dept Radiat Oncol, Nanjing, Jiangsu, Peoples R China
2.Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Nanjing, Jiangsu, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiat Oncol, Beijing 100871, Peoples R China

Recommended Citation:
Yu, Hongliang,Yin, Li,Jiang, Xuesong,et al. Effect of Metformin on Cancer Risk and Treatment Outcome of Prostate Cancer: A Meta-Analysis of Epidemiological Observational Studies[J]. PLOS ONE,2014,9(12).
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