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Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles
Wang, Yun1; Chen, Zhangjian1; Ba, Te1; Pu, Ji1; Chen, Tian1; Song, Yanshuang1; Gu, Yongen1; Qian, Qin1; Xu, Yingying2; Xiang, Kun2; Wang, Haifang3; Jia, Guang1
关键词titanium dioxide nanoparticles oral toxicity liver injury
刊名SMALL
2013-05-27
DOI10.1002/smll.201201185
9期:9-10页:1742-1752
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]ULTRAFINE PARTICLES ; HEART-FAILURE ; MAST-CELLS ; MICE ; GLUTATHIONE ; DISEASE ; STRESS ; SIZE ; CARDIOMYOPATHY ; PROTECTION
英文摘要

Titanium dioxide nanoparticles (TiO2 NPs) have potential applications as food additives, but concerns persist about their safety. Children are identified as having the highest exposure and may face the greatest health risks. However, the toxicological sensitivity of TiO2 NPs in different ages is not clear. Here, a comparative toxicity study of TiO2 NPs in 3-week (youth) and 8-week (adult) old Sprague-Dawley rats is reported following oral exposure at doses of 0, 10, 50, 200 mg kg1 body weight per day for 30 days. The organ mass and histology, blood biochemistry and redox state, intestinal function, and biodistribution of NPs are characterized. The results show that TiO2 NPs induce different toxic effects on young and adult rats. The liver edema, heart injuries and non-allergic mast cell activation in stomach tissues are found in young rats. On the other hand, only slight injury in the liver and kidney and decreased intestinal permeability and molybdenum contents are found in adult rats. Furthermore, TiO2 NP exposure can provoke reductive stress (i.e., increased reduced glutathione (GSH)/oxidized glutathione (GSSG) ratios) in plasmas through enhancing the glucose and GSH levels in young rats or reducing the glutathione peroxidase (GSH-Px) acitivity and GSSG levels in adult rats. These results suggest that different ages may require different biomarkers for identifying and monitoring oral toxicity of nanoparticles.

语种英语
WOS记录号WOS:000319076000029
项目编号2011CB933402 ; 20110001120027 ; BMU20100085
资助机构National Basic Research Program of China (973 Program) ; Specialized Research Fund for the Doctoral Program of Higher Education of China (New Teachers) ; Start-Up Fund for New Teachers of Peking University Health Science Center
引用统计
被引频次:55[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60870
专题北京大学公共卫生学院
北京大学医学部管理机构_科学研究处
北京大学公共卫生学院_公共卫生学院
北京大学第二临床医学院_放射科
作者单位1.Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yun,Chen, Zhangjian,Ba, Te,et al. Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles[J]. SMALL,2013,9(9-10):1742-1752.
APA Wang, Yun.,Chen, Zhangjian.,Ba, Te.,Pu, Ji.,Chen, Tian.,...&Jia, Guang.(2013).Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles.SMALL,9(9-10),1742-1752.
MLA Wang, Yun,et al."Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles".SMALL 9.9-10(2013):1742-1752.
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