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学科主题: 公共卫生
题名:
Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles
作者: Wang, Yun1; Chen, Zhangjian1; Ba, Te1; Pu, Ji1; Chen, Tian1; Song, Yanshuang1; Gu, Yongen1; Qian, Qin1; Xu, Yingying2; Xiang, Kun2; Wang, Haifang3; Jia, Guang1
关键词: titanium dioxide ; nanoparticles ; oral toxicity ; liver injury
刊名: SMALL
发表日期: 2013-05-27
DOI: 10.1002/smll.201201185
卷: 9, 期:9-10, 页:1742-1752
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: ULTRAFINE PARTICLES ; HEART-FAILURE ; MAST-CELLS ; MICE ; GLUTATHIONE ; DISEASE ; STRESS ; SIZE ; CARDIOMYOPATHY ; PROTECTION
英文摘要:

Titanium dioxide nanoparticles (TiO2 NPs) have potential applications as food additives, but concerns persist about their safety. Children are identified as having the highest exposure and may face the greatest health risks. However, the toxicological sensitivity of TiO2 NPs in different ages is not clear. Here, a comparative toxicity study of TiO2 NPs in 3-week (youth) and 8-week (adult) old Sprague-Dawley rats is reported following oral exposure at doses of 0, 10, 50, 200 mg kg1 body weight per day for 30 days. The organ mass and histology, blood biochemistry and redox state, intestinal function, and biodistribution of NPs are characterized. The results show that TiO2 NPs induce different toxic effects on young and adult rats. The liver edema, heart injuries and non-allergic mast cell activation in stomach tissues are found in young rats. On the other hand, only slight injury in the liver and kidney and decreased intestinal permeability and molybdenum contents are found in adult rats. Furthermore, TiO2 NP exposure can provoke reductive stress (i.e., increased reduced glutathione (GSH)/oxidized glutathione (GSSG) ratios) in plasmas through enhancing the glucose and GSH levels in young rats or reducing the glutathione peroxidase (GSH-Px) acitivity and GSSG levels in adult rats. These results suggest that different ages may require different biomarkers for identifying and monitoring oral toxicity of nanoparticles.

语种: 英语
所属项目编号: 2011CB933402 ; 20110001120027 ; BMU20100085
项目资助者: National Basic Research Program of China (973 Program) ; Specialized Research Fund for the Doctoral Program of Higher Education of China (New Teachers) ; Start-Up Fund for New Teachers of Peking University Health Science Center
WOS记录号: WOS:000319076000029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60870
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China

Recommended Citation:
Wang, Yun,Chen, Zhangjian,Ba, Te,et al. Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles[J]. SMALL,2013,9(9-10):1742-1752.
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