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学科主题临床医学
The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis
Gao, L.; Cheng, H. Y.; Dong, L.; Ye, X.; Liu, Y. N.; Chang, X. H.; Cheng, Y. X.; Chen, J.; Ma, R. Q.; Cui, H.
关键词HUMAN EPIDIDYMIS PROTEIN 4 (HE4) OVARIAN CANCER APOPTOSIS CELL PROLIFERATION METASTASIS
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2011-09-01
39期:5页:1645-1660
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]PROTEINASE-INHIBITORS ; ENDOMETRIOTIC CYSTS ; PROTEASE INHIBITOR ; PELVIC MASS ; SERUM HE-4 ; BIOMARKER ; EXPRESSION ; CARCINOMA ; MULTIPLE ; MARKER
英文摘要

As a promising biomarker, human epididymis protein 4 (HE4) has been widely used for the early detection and differential diagnosis of ovarian cancer. This study evaluated the function of HE4 in the carcinogenesis and progression of ovarian cancer. An enzyme immunometric assay, used to detect HE4 in the serum of ovarian cancer patients, showed that the protein could discriminate between malignant and benign ovarian tumours with high specificity. An exogenous HE4 gene was transfected into ovarian cancer cell lines and an immortalized ovarian epithelial cell line. Compared with the controls, HE4 overexpression significantly promoted cell apoptosis and adhesion. Overexpression of HE4 also led to significant inhibition of cell proliferation, migration and invasiveness in vitro, as well as xenograft tumour formation in vivo. This is the first report to demonstrate the functional importance of HE4 in multiple cellular processes and indicates that HE4 may play a protective role in the progression of ovarian cancer.

语种英语
WOS记录号WOS:000297532400007
项目编号81172454 ; 20100001110079 ; RDB2010-11
资助机构National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Peking University People&prime ; s Hospital
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60872
专题北京大学临床肿瘤学院_肿瘤放疗科
北京大学第一临床医学院_临床药理研究所
北京大学第二临床医学院_妇科肿瘤中心
作者单位Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China
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GB/T 7714
Gao, L.,Cheng, H. Y.,Dong, L.,et al. The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2011,39(5):1645-1660.
APA Gao, L..,Cheng, H. Y..,Dong, L..,Ye, X..,Liu, Y. N..,...&Cui, H..(2011).The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,39(5),1645-1660.
MLA Gao, L.,et al."The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 39.5(2011):1645-1660.
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