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学科主题: 临床医学
题名:
The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis
作者: Gao, L.; Cheng, H. Y.; Dong, L.; Ye, X.; Liu, Y. N.; Chang, X. H.; Cheng, Y. X.; Chen, J.; Ma, R. Q.; Cui, H.
关键词: HUMAN EPIDIDYMIS PROTEIN 4 (HE4) ; OVARIAN CANCER ; APOPTOSIS ; CELL PROLIFERATION ; METASTASIS
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2011-09-01
卷: 39, 期:5, 页:1645-1660
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: PROTEINASE-INHIBITORS ; ENDOMETRIOTIC CYSTS ; PROTEASE INHIBITOR ; PELVIC MASS ; SERUM HE-4 ; BIOMARKER ; EXPRESSION ; CARCINOMA ; MULTIPLE ; MARKER
英文摘要:

As a promising biomarker, human epididymis protein 4 (HE4) has been widely used for the early detection and differential diagnosis of ovarian cancer. This study evaluated the function of HE4 in the carcinogenesis and progression of ovarian cancer. An enzyme immunometric assay, used to detect HE4 in the serum of ovarian cancer patients, showed that the protein could discriminate between malignant and benign ovarian tumours with high specificity. An exogenous HE4 gene was transfected into ovarian cancer cell lines and an immortalized ovarian epithelial cell line. Compared with the controls, HE4 overexpression significantly promoted cell apoptosis and adhesion. Overexpression of HE4 also led to significant inhibition of cell proliferation, migration and invasiveness in vitro, as well as xenograft tumour formation in vivo. This is the first report to demonstrate the functional importance of HE4 in multiple cellular processes and indicates that HE4 may play a protective role in the progression of ovarian cancer.

语种: 英语
所属项目编号: 81172454 ; 20100001110079 ; RDB2010-11
项目资助者: National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Peking University People&prime ; s Hospital
WOS记录号: WOS:000297532400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60872
Appears in Collections:北京大学第二临床医学院_妇科肿瘤中心_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Gao, L.,Cheng, H. Y.,Dong, L.,et al. The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2011,39(5):1645-1660.
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