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学科主题: 临床医学
题名:
Effect of Doxazosin Gastrointestinal Therapeutic System 4 mg vs Tamsulosin 0.2 mg on Nocturia in Chinese Men With Lower Urinary Tract Symptoms: A Prospective, Multicenter, Randomized, Open, Parallel Study
作者: Zhang, Kai; Yu, Wei1; Jin, Jie; Ye, Haiyun; Wang, Xiaofeng; Zhang, Ning; Yang, Yong; Zhong, Chenyang; Wan, Ben
刊名: UROLOGY
发表日期: 2011-09-01
DOI: 10.1016/j.urology.2011.04.038
卷: 78, 期:3, 页:636-640
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: BENIGN PROSTATIC HYPERPLASIA ; ASIAN MEN ; HYDROCHLORIDE ; ANTAGONISTS ; ALFUZOSIN ; EFFICACY ; QUALITY ; BLADDER ; SLEEP
英文摘要:

OBJECTIVE To compare the efficacy of the doxazosin gastrointestinal therapeutic system (doxazosin-GITS) 4 mg and tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH).

METHODS Data were analyzed from a prospective, multicenter, randomized, open, parallel study of Chinese men aged 50-84 years with LUTS/BPH. Two hundred patients were randomized to receive daily treatment with 4 mg doxazosin-GITS (n = 100) or 0.2 mg tamsulosin (n = 100) for 8 weeks. Nocturia was assessed by question 7 of the International Prostate Symptom Score (IPSS-question 7) and a frequency-volume chart (FVC) at weeks 4 and 8. Self-reported quality of sleep and quality of life by the last question of the IPSS questionnaire were also evaluated.

RESULTS A total of 189 patients (94 receiving doxazosin-GITS, 95 tamsulosin) completed the study. The reduction from baseline in mean nocturia was greater with doxazosin-GITS than tamsulosin by the FVC (1.7 vs 1.3 at week 4; 2.1 vs 1.7 at week 8, both P = .001) and by the IPSS-question 7 (1.5 vs 1.1 at 4 weeks, P = .001; 2.0 vs 1.6 at 8 weeks, P < .001). The patients who reported improved quality of sleep was significantly more with doxazosin-GITS than tamsulosin (43.6% vs 27.4% at 4 weeks, P = .020; 81.9% vs 67.4% at 8 weeks, P = .022), and quality of life was better with doxazosin-GITS (2.5 vs 2.8 at 4 weeks, P = .001; 2.1 vs 2.5 at 8 weeks, P < .001).

CONCLUSION In Chinese patients with LUTS/BPH, doxazosin-GITS is slightly better than tamsulosin in reducing the frequency of nocturia. UROLOGY 78: 636-640, 2011. (C) 2011 Elsevier Inc.

语种: 英语
WOS记录号: WOS:000294483300051
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60874
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
2.Beijing Chao Yang Hosp, Dept Urol, Beijing, Peoples R China
3.Beijing Hosp, Dept Urol, Beijing, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Kai,Yu, Wei,Jin, Jie,et al. Effect of Doxazosin Gastrointestinal Therapeutic System 4 mg vs Tamsulosin 0.2 mg on Nocturia in Chinese Men With Lower Urinary Tract Symptoms: A Prospective, Multicenter, Randomized, Open, Parallel Study[J]. UROLOGY,2011,78(3):636-640.
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