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The stomach cancer pooling (StoP) project: study design and presentation
Pelucchi, Claudio1; Lunet, Nuno5,6; Boccia, Stefania3,4; Zhang, Zuo-Feng7,8; Praud, Delphine1,2; Boffetta, Paolo9,10; Levi, Fabio15; Matsuo, Keitaro16; Ito, Hidemi17; Hu, Jinfu18; Johnson, Kenneth C.19; Ferraroni, Monica2; Yu, Guo-Pei33; Peleteiro, Barbara5,6; Malekzadeh, Reza21; Derakhshan, Mohammad H.21,23; Ye, Weimin24; Zaridze, David26; Maximovitch, Dmitry26; Aragones, Nuria27,28,29; Martin, Vicente28,30; Pakseresht, Mohammadreza20,21; Pourfarzi, Farhad21,22; Bellavia, Andrea25; Orsini, Nicola25; Wolk, Alicja25; Mu, Lina12; Arzani, Dario3; Kurtz, Robert C.11; Lagiou, Pagona31,32; Trichopoulos, Dimitrios13,32; Muscat, Joshua14; La Vecchia, Carlo1,2; Negri, Eva1
关键词consortia epidemiology pooled analysis risk factors stomach neoplasms
WOS标题词Science & Technology
资助者Italian Ministry of Health ; Italian Ministry of Health

Gastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income countries. We introduce a consortium of epidemiological investigations named the Stomach cancer Pooling (StoP) Project′. Twenty-two studies agreed to participate, for a total of over 9000 cases and 23 000 controls. Twenty studies have already shared the original data set. Of the patients, 40% are from Asia, 43% from Europe, and 17% from North America; 34% are women and 66% men; the median age is 61 years; 56% are from population-based case-control studies, 41% from hospital-based ones, and 3% from nested case-control studies derived from cohort investigations. Biological samples are available from 12 studies. The aim of the StoP Project is to analyze the role of lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data. The uniquely large data set will allow us to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, we will carry out separate analyses according to different histotypes and subsites of gastric cancer, to identify potential different risk patterns and etiological characteristics. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

资助者Italian Ministry of Health ; Italian Ministry of Health
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作者单位1.Univ Porto ISPUP, Inst Publ Hlth, Oporto, Portugal
2.Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA
3.Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA
4.Kyushu Univ, Fac Med Sci, Dept Prevent Med, Fukuoka 812, Japan
5.Ardabil Univ Med Sci, Dept Community Med, Ardebil, Iran
6.Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy
7.IRCCS San Raffaele Pisana, Rome, Italy
8.IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, I-20156 Milan, Italy
9.Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Rome, Italy
10.Univ Porto, Sch Med, Dept Clin Epidemiol Predict Med & Publ Hlth, P-4100 Oporto, Portugal
11.Univ Calif Los Angeles, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA
12.Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY USA
13.Mem Sloan Kettering Canc Ctr, Rockville Ctr, New York, NY 10065 USA
14.SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY 14260 USA
15.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
16.Penn State Coll Med, Hershey, PA USA
17.Univ Lausanne Hosp, Inst Social & Prevent Med IUMSP, Canc Epidemiol Unit, Lausanne, Switzerland
18.Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan
19.Publ Hlth Agcy Canada, Social Determinants & Sci Integrat Directorate, Sci Integrat Div, Calgary, AB, Canada
20.Univ Ottawa, Dept Epidemiol & Community Hlth, Ottawa, ON, Canada
21.Univ Alberta, Dept Med, Aboriginal & Global Hlth Res Grp, Edmonton, AB, Canada
22.Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran
23.Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
24.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
25.Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-10401 Stockholm, Sweden
26.Russian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia
27.Inst Salud Carlos III, Natl Ctr Epidemiol, Environm & Canc Epidemiol Unit, Madrid, Spain
28.CIBERESP, Madrid, Spain
29.IIS Puerta Hierro, Majadahonda, Spain
30.Univ Leon, E-24071 Leon, Spain
31.Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece
32.Acad Athens, Bur Epidemiol Res, Athens, Greece
33.Peking Univ, Med Informat Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Pelucchi, Claudio,Lunet, Nuno,Boccia, Stefania,et al. The stomach cancer pooling (StoP) project: study design and presentation[J]. EUROPEAN JOURNAL OF CANCER PREVENTION,2015,24(1):16-23.
APA Pelucchi, Claudio.,Lunet, Nuno.,Boccia, Stefania.,Zhang, Zuo-Feng.,Praud, Delphine.,...&Negri, Eva.(2015).The stomach cancer pooling (StoP) project: study design and presentation.EUROPEAN JOURNAL OF CANCER PREVENTION,24(1),16-23.
MLA Pelucchi, Claudio,et al."The stomach cancer pooling (StoP) project: study design and presentation".EUROPEAN JOURNAL OF CANCER PREVENTION 24.1(2015):16-23.
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