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Desmoplastic small round cell tumor of the submandibular gland-a rare but distinctive primary salivary gland neoplasm
Yin, Wei-Hua2; Guo, Shuang-Ping1; Yang, Hong-Yu2; Chan, John K. C.3
关键词Salivary gland tumor Desmoplastic small round cell tumor Molecular analysis EWS/WT1 gene fusion
刊名HUMAN PATHOLOGY
2010-03-01
DOI10.1016/j.humpath.2009.08.015
41期:3页:438-442
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]SPECTRUM
英文摘要

Desmoplastic small round cell tumor is a highly aggressive neoplasm that generally involves the peritoneum and pelvis of young patients. Only rare cases occur outside the abdomen. We report a case presenting as a primary submandibular gland tumor in a 24-year-old man. Histologically, although there were irregular tumor islands lying in an abundant desmoplastic stroma, there were also areas comprising large cellular islands with scanty stroma in between, raising the differential diagnosis of various salivary gland carcinomas. The tumor cells were medium sized, with hyperchromatic nuclei and moderate amounts of cytoplasm. The diagnosis of desmoplastic small round cell tumor was confirmed by the presence of a polyphenotypic immunoprofile (positive for cytokeratin, desmin, and neuron-specific enolase) and the characteristic EWS-WT1 gene fusion. Although rare, desmoplastic small round cell tumor has to be considered in the differential diagnosis of poorly differentiated neoplasms of the salivary gland, especially in young patients. (C) 2010 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000276493700017
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60878
专题北京大学深圳医院_病理科
作者单位1.Fourth Mil Med Univ, Xi Jing Hosp, Dept Pathol, Xian 710032, Peoples R China
2.Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Pathol, Shenzhen 518001, Peoples R China
推荐引用方式
GB/T 7714
Yin, Wei-Hua,Guo, Shuang-Ping,Yang, Hong-Yu,et al. Desmoplastic small round cell tumor of the submandibular gland-a rare but distinctive primary salivary gland neoplasm[J]. HUMAN PATHOLOGY,2010,41(3):438-442.
APA Yin, Wei-Hua,Guo, Shuang-Ping,Yang, Hong-Yu,&Chan, John K. C..(2010).Desmoplastic small round cell tumor of the submandibular gland-a rare but distinctive primary salivary gland neoplasm.HUMAN PATHOLOGY,41(3),438-442.
MLA Yin, Wei-Hua,et al."Desmoplastic small round cell tumor of the submandibular gland-a rare but distinctive primary salivary gland neoplasm".HUMAN PATHOLOGY 41.3(2010):438-442.
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