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Thymidine-based amphiphiles and their bonding to DNA
Pan, Delin; Tang, Chen; Fan, Xinmeng; Li, Yating; Yang, Xiantao; Jin, Hongwei; Guan, Zhu; Yang, Zhenjun; Zhang, Lihe
刊名NEW JOURNAL OF CHEMISTRY
2013
DOI10.1039/c3nj41062e
37期:4页:1122-1127
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]SUPRAMOLECULAR ASSEMBLIES ; NUCLEIC-ACID ; MOLECULAR RECOGNITION ; GENE DELIVERY ; NUCLEOSIDE ; OLIGONUCLEOTIDE ; NUCLEOTIDE ; PEPTIDE ; COMPLEXES ; CHEMISTRY
英文摘要

To develop non-cationic vectors for gene delivery, a novel class of thymidine-based amphiphiles have been constructed. These molecules showed good biocompatibility. Their complexation with polyadenylic acid through hydrogen bonding and pi-pi stacking interaction was demonstrated by gel electrophoresis, capillary electrophoresis, transmission electronic microscopy (TEM) and molecular dynamics simulation. It was also found that their biocompatibility and binding ability with DNA varied inversely with the length of the alkyl chains.

语种英语
WOS记录号WOS:000316225300033
项目编号2012CB720604 ; 20932001
资助机构Ministry of Science and Technology of China ; NNSFC
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60881
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_药物化学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Pan, Delin,Tang, Chen,Fan, Xinmeng,et al. Thymidine-based amphiphiles and their bonding to DNA[J]. NEW JOURNAL OF CHEMISTRY,2013,37(4):1122-1127.
APA Pan, Delin.,Tang, Chen.,Fan, Xinmeng.,Li, Yating.,Yang, Xiantao.,...&Zhang, Lihe.(2013).Thymidine-based amphiphiles and their bonding to DNA.NEW JOURNAL OF CHEMISTRY,37(4),1122-1127.
MLA Pan, Delin,et al."Thymidine-based amphiphiles and their bonding to DNA".NEW JOURNAL OF CHEMISTRY 37.4(2013):1122-1127.
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