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Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization
Wang, Deqian1,2; Liu, Ruigang1; Che, Ning1,2; Li, Qinmei1,2; Li, Zhuang1,2; Tian, Ye1,2; Kang, Honglang1; Jia, Bing3; Huang, Yong1,4
刊名POLYMER CHEMISTRY
2011
DOI10.1039/c1py00168j
2期:8页:1872-1878
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]IN-VIVO BIODISTRIBUTION ; HPMA COPOLYMERS ; DRUG-DELIVERY ; POLYMER ; DOXORUBICIN ; VITRO ; NANOPARTICLES ; CYTOTOXICITY ; VASCULATURE ; THERAPY
英文摘要

Dextran graft copolymers, including dextran graft poly(N-methacryloylglycylglycine) copolymers conjugated with polyethylene glycol and tyrosine (Dex-g-PMAGGCONHPEG(3k)-NHTyr), dextran graft poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-P(HPMA-co-MAGGCONHTyr)), and dextran graft poly(methacrylpolyethylene glycol-co-N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-P(MPEG-co-MAGGCONHTyr)) were synthesized for the purpose to improve the biodistribution and blood clearance time of ploy(N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-PMAGGCONHTyr). Dynamic light scattering (DLS) results indicated that no aggregation formed in 0.9% saline solution. The graft copolymers were labeled with I-125 and the labeled copolymers are stable in 0.9% saline and 1% BSA of PBS solutions. Pharmacokinetics studies showed that I-125 labeled graft copolymer Dex-g-P(HPMA-co-MAGGCONHTyr) had a longer blood clearance time than the others. Biodistribution images confirmed the preferable liver and spleen accumulation at 1 h after injection, and especially for blood tissue, the mean %ID/g value of the PHPMA-modified graft copolymer Dex-g-P(HPMA-co-MAGGCONHTyr) is 7 folds higher than that of Dex-g-PMAGGCONHTyr.

语种英语
WOS记录号WOS:000292965500036
项目编号20974114 ; 50821062 ; KJCX2-YW-H19
资助机构National Natural Science Foundation of China ; Chinese Academy of Sciences
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60884
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Tech Inst Phys & Chem, Natl Res Ctr Engn Plast, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Wang, Deqian,Liu, Ruigang,Che, Ning,et al. Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization[J]. POLYMER CHEMISTRY,2011,2(8):1872-1878.
APA Wang, Deqian.,Liu, Ruigang.,Che, Ning.,Li, Qinmei.,Li, Zhuang.,...&Huang, Yong.(2011).Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization.POLYMER CHEMISTRY,2(8),1872-1878.
MLA Wang, Deqian,et al."Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization".POLYMER CHEMISTRY 2.8(2011):1872-1878.
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