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学科主题: 公共卫生
题名:
Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization
作者: Wang, Deqian1,2; Liu, Ruigang1; Che, Ning1,2; Li, Qinmei1,2; Li, Zhuang1,2; Tian, Ye1,2; Kang, Honglang1; Jia, Bing3; Huang, Yong1,4
刊名: POLYMER CHEMISTRY
发表日期: 2011
DOI: 10.1039/c1py00168j
卷: 2, 期:8, 页:1872-1878
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Polymer Science
研究领域[WOS]: Polymer Science
关键词[WOS]: IN-VIVO BIODISTRIBUTION ; HPMA COPOLYMERS ; DRUG-DELIVERY ; POLYMER ; DOXORUBICIN ; VITRO ; NANOPARTICLES ; CYTOTOXICITY ; VASCULATURE ; THERAPY
英文摘要:

Dextran graft copolymers, including dextran graft poly(N-methacryloylglycylglycine) copolymers conjugated with polyethylene glycol and tyrosine (Dex-g-PMAGGCONHPEG(3k)-NHTyr), dextran graft poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-P(HPMA-co-MAGGCONHTyr)), and dextran graft poly(methacrylpolyethylene glycol-co-N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-P(MPEG-co-MAGGCONHTyr)) were synthesized for the purpose to improve the biodistribution and blood clearance time of ploy(N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-PMAGGCONHTyr). Dynamic light scattering (DLS) results indicated that no aggregation formed in 0.9% saline solution. The graft copolymers were labeled with I-125 and the labeled copolymers are stable in 0.9% saline and 1% BSA of PBS solutions. Pharmacokinetics studies showed that I-125 labeled graft copolymer Dex-g-P(HPMA-co-MAGGCONHTyr) had a longer blood clearance time than the others. Biodistribution images confirmed the preferable liver and spleen accumulation at 1 h after injection, and especially for blood tissue, the mean %ID/g value of the PHPMA-modified graft copolymer Dex-g-P(HPMA-co-MAGGCONHTyr) is 7 folds higher than that of Dex-g-PMAGGCONHTyr.

语种: 英语
所属项目编号: 20974114 ; 50821062 ; KJCX2-YW-H19
项目资助者: National Natural Science Foundation of China ; Chinese Academy of Sciences
WOS记录号: WOS:000292965500036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60884
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Tech Inst Phys & Chem, Natl Res Ctr Engn Plast, Beijing 100190, Peoples R China

Recommended Citation:
Wang, Deqian,Liu, Ruigang,Che, Ning,et al. Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization[J]. POLYMER CHEMISTRY,2011,2(8):1872-1878.
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